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Probiotics in human disease

http://www.firstlight.cn2016/6/14

[作者] Erika Isolauri

[摘要] Western civilization is facing a progressive increase in immune-mediated, gut-related health problems, such as allergies and autoimmune and inflammatory diseases, and genetic factors are an unlikely explanat…

[关键词] Atopy diarrhea food allergy

Western civilization is facing a progressive

increase in immune-mediated, gut-related health problems, such

as allergies and autoimmune and inflammatory diseases, and

genetic factors are an unlikely explanation for these rapid

increases in disease incidence. Two environmental factors that

relate to the modern lifestyle in Western societies are hygiene

and nutrition. There has been a decline in the incidence of microbial

stimulation by infectious diseases as a result of improved

hygiene, vaccination, and antimicrobial medication. In the past,

methods of food preservation involved either the natural fermentation

or drying of foods; thus, the human diet once contained

several thousand times more bacteria than it does today. The

development of probiotic, functional foods aims to “kill two

birds with one stone,” which is accomplished by providing a

microbial stimulus to the host immune system by means of beneficial

live microorganism cultures that are characteristic of the

healthy, human gut microflora, ie, probiotics. Probiotic bacteria

were shown to reinforce the different lines of gut defense, which

are immune exclusion, immune elimination, and immune regulation.

They were also shown to stimulate nonspecific host resistance

to microbial pathogens, thereby aiding in pathogen eradication.

Consequently, the best documented clinical application of probiotics

is in the treatment of acute diarrhea. In humans, documented

effects were reported for the alleviation of intestinal

inflammation, normalization of gut mucosal dysfunction, and

down-regulation of hypersensitivity reactions. These data show

that probiotics promote endogenous host defense mechanisms.

Thus, modification of gut microflora by probiotic therapy may

offer a therapeutic potential in clinical conditions associated

with gut-barrier dysfunction and inflammatory response.

存档附件原文地址

原文发布时间:2016/6/14

引用本文:

Erika Isolauri.Probiotics in human diseasehttp://hftc.firstlight.cn/View.aspx?infoid=3644303&cb=Z09890000000
发布时间:2016/6/14.检索时间:2024/12/13

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