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肢端型黑色素瘤（acral melanoma, AM）是一种起源于手掌、足底和甲下等部位的恶性皮肤肿瘤，也是亚洲人群中最主要的黑色素瘤亚型。原位AM（AM in situ, AMis）突破基底膜进入真皮发展为侵袭性AM（invasive AM, iAM）是造成患者预后变差的重要里程碑事件。然而，目前关于AMis的研究仍然十分有限，AMis向iAM的演化过程尚不清楚，免疫微环境在这一过程中发挥的作用...
近日，空军军医大学唐都医院心血管内科李妍教授团队在生物医学领域权威期刊《Cell Death＆Differentiation》（IF：12.4，JCR：Q1，中科院分区：1区）发表题为 《Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis》...
Multifocal Skeletal Tuberculosis Mimicking Langerhans Cell Histiocytosis in a Child: a Case Report With a Long-Term Follow-Up
Tuberculosis Bone and Bones Spine
2015/12/29
Introduction: Multifocal skeletal tuberculosis is a rare condition that may masquerade as Langerhans cell histiocytosis, especially in children.
Small Cell Carcinoma of the Esophagus: Clinicopathological Features and Outcome of 22 Cases
Small Cell Carcinoma Esophagus Prognosis Surgical Procedures Chemotherapy
2015/11/9
Background: Small cell esophageal carcinoma (SCEC) is a highly aggressive and rare neoplasm.
Unusual Growth of Upper Lip Squamous Cell Carcinoma: A Case Report
Squamous Cell Carcinoma Skin Prognosis Pathology
2015/10/22
Introduction: Squamous cell carcinoma is the most common type of lip and oral cavity cancers. In majority of cases it follows quite common course, and after the surgery it does not produce any harm. T...
Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma
Retinoic acid Cellular retinoic acid-binding proteins Histone deacetylase Renal cell carcinoma
2015/7/28
Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation whic...
Squamous Cell Carcinoma of Endometrium with Extensive Icthyosis Uteri
Squamous cell carcinoma Endometrium Icthyosis uteri Vaginal bleeding
2015/7/21
We report a rare case of squamous cell carcinoma of endometrium arising in icthyosis uteri in a 60 years old lady presenting with vaginal bleeding.
An Unusual Melanocytic Nevus of Conjunctiva : Balloon Cell Nevus
Nevi Balloon cell Conjunctiva
2015/7/21
Melanocytic nevi are one of the most common benign tumors of the conjunctiva. The balloon cell nevus is a rare and unusual variant of nevus of melanocytic origin, in which more than 50% of the tumor i...
Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun®,on body composition,muscle strength and mass,markers of satellite cell activation, and clinical safety markers in males
28 days of resistance exercise consuming a commercially available pre-workout supplement NO-Shotgun on body composition muscle strength and mass markers of satellite cell activation clinical safety markers in males
2015/7/16
This study determined the effects of 28 days of heavy resistance exercise combined with the nutritional supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellit...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
Reactive Oxygen Species, Mitochondria, and Endothelial Cell Death during In Vitro Simulated Dives
SCUBA DIVING OXIDATIVE STRESS REACTIVE OXYGEN SPECIES MITOCHONDRIAL MEMBRANE POTENTIAL CELL DEATH ENDOTHELIAL DYSFUNCTION
2017/4/19
Purpose: Excessive reactive oxygen species (ROS) is considered a consequence of hyperoxia and a major contributor to diving-derived vascular endothelial damage and decompression sickness. The aims of ...
Influence Of Chronic Exercise On Red Cell Antioxidant Defense, Plasma Malondialdehyde And Total Antioxidant Capacity In Hypercholesterolemic Rabbits
Chronic exercise antioxidant malondialdehyde thiol atherosclerosis
2015/3/23
weeks, 60 male Dutch rabbits were fed rabbit chow with or without the addition of 2% cholesterol. The animals were further divided into rest and exercise groups (n = 15 for each group). Animals in exe...
Effects of High-Impact Mechanical Loading on Synovial Cell Cultures
Impulsive factor rheumatoid arthritis synovium MMP
2015/3/12
Cartilage metabolism in response to mechanical loading is an important subject in sports science and medicine. In animal studies high-impact exercise is known to stimulate bone adaptation and increase...
Repression of cyclin D1 as a target for germ cell tumors
metastatic germ cell tumors cyclin D1
2014/12/12
Metastatic germ cell tumors (GCT) are curable, however GCTs refractory to cisplatin-based chemotherapy have a poor prognosis. This study explores D-type cyclins as molecular targets in GCTs because al...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...