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深圳北京大学香港科技大学医学中心詹启敏/崔永萍团队新发表在National Science Review杂志上的论文揭示了食管癌中免疫与肿瘤互作驱动的空间定向进化(图)
食管癌 死亡率 食管鳞状细胞癌
2024/7/9
目前,食管癌的发病率与死亡率在全球范围内均排在前列,超过一半以上的患者发生在我国,其中约90%的病理类型为食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)。通过以往的研究发现,食管鳞癌在基因组变异和肿瘤微环境等方面均具有广泛的肿瘤异质性,而造成食管鳞癌异质性的原因尚不清楚。因此,充分了解肿瘤异质性的特征以及其形成机制将有助于指导食管鳞癌药物开发以及临...
Review of National and International Accreditation of Pharmacy Programs in the Gulf Cooperation Council Countries
international accreditation pharmacy education Gulf Cooperation Council (GCC) countries ACPE certification program national accreditation
2019/1/7
Objective. To compare the different philosophies, emphases and processes of national and international accreditation paths available to pharmacy programs in Gulf Cooperation Council (GCC) countries.To...
Issues and Opportunities on Implementing an Online Faculty Review System
Issues Opportunities Implementing Online Faculty
2018/11/22
Intensifying accountability pressures have led to an increased attention to assessments of teaching, but teaching generally represents only a portion of faculty duties. Less attention has been paid to...
Review of Grit and Resilience Literature within Health Professions Education
Review Resilience Literature Health Professions Education
2018/11/21
Objective. To review literature pertaining to grit and resilience in health professions education.
Findings. There is significant interest in grit and resilience throughout the health professions, bu...
A Scoping Review of Peer-led Education in Patient Safety Training
Scoping Review Peer-led Education Patient Safety Training
2018/11/21
Objective. To examine the literature pertaining to the use of peer-led education in patient safety.
Findings. Four studies met the inclusion criteria: two were conducted in health care students and t...
Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials
body composition glucose insulin meta-analysis soluble fiber supplementation
2018/11/21
Background: There is strong epidemiologic evidence that dietary fiber intake is protective against overweight and obesity; however, results of intervention studies have been mixed. Soluble fiber benef...
Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis
short-chain fatty acids prebiotics synbiotics C-reactive protein IL-6 TNF-α systemic inflammation humans
2018/11/16
Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory effects.
Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
allergic disease n–3 LC-PUFA pregnancy allergy prevention fatty acids randomized controlled trial prenatal supplementation asthma eczema hayfever
2018/11/23
Background: There is some evidence that increased maternal intake of omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)...
Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: a systematic review and meta-analysis
hypercalcemia hypercalciuria kidney stones randomized controlled trials vitamin D supplements
2018/12/18
Background: Vitamin D supplementation is increasingly being used in higher doses in randomized controlled trials (RCTs). However, adverse events from very large annual doses of vitamin D have been sho...
Potatoes and risk of obesity, type 2 diabetes, and cardiovascular disease in apparently healthy adults: a systematic review of clinical intervention and observational studies
adiposity french fry glycemic index potato solanum tuberosum
2018/12/13
Background: Potatoes have been related to increased risks of obesity, type 2 diabetes (T2D), and cardiovascular disease (CVD) mainly because of their high glycemic index.
Flavonoids: a review of probable mechanisms of action and potential applications
Flavonoids bioflavonoids antioxidants
2016/6/14
The aim of this review, a summary of the putative
biological actions of flavonoids, was to obtain a further
understanding of the reported beneficial health effects of these
substances. Flavonoids o...
Lessons for search strategies from a systematic review, in The Cochrane Library, of nutritional supplementation trials in patients after hip fracture
Systematic reviews meta-analysis randomized controlled trials
2016/6/12
A key aim when conducting systematic reviews of
randomized controlled trials (RCTs) is to include all of the evidence,
if possible. Serious bias may result if trials are missed
through inadequate s...
Hydration of fat-free body mass: review and critique of a classic body-composition constant
body composition mammals dual-energy X-ray absorptiometry
2016/5/31
The assumed “constancy” of fat-free body
mass hydration is a cornerstone in the body-composition
research field. Hydration, the observed ratio of total body water
to fat-free body mass, is stable a...
Do Basketball Players Have a High Risk of Pulmonary Embolism? A Scoping Review
PREVENTION SPORTS INJURY INCIDENCE DIAGNOSIS ILLNESS
2017/4/13
Purpose: Pulmonary embolism (PE) is a serious preventable disease that requires urgent care. In recent years, there have been several reports in the media about basketball players experiencing PE. The...
Confectionery consumption and overweight, obesity, and related outcomes in children and adolescents: a systematic review and meta-analysis
adolescent candy child obesity overweight
2018/11/30
Background: Many calorie-rich dietary components contribute to obesity. However, the contribution of confectionery to obesity in children and adolescents has not been well established.