搜索结果: 1-15 共查到“知识库 Bioinformatics”相关记录21条 . 查询时间(0.078 秒)
Briefings in Bioinformatics丨杨力团队开发RNAlight工具用于多类型RNA的亚细胞定位预测研究（图）
杨力团队 RNA亚细胞 生物医学研究院 核苷酸序列
2023/4/14
RNA亚细胞定位与其生成、加工和功能密切相关（1,2），因此，解析RNA的亚细胞定位对其功能研究至关重要。利用传统的实验生物学方法，如FISH和细胞组分分离后鉴定等可以有效的发现目的RNA的亚细胞定位，但是其通量较低、且不同实验方法的特异性也会导致某些RNA无法被准确定位。近期，结合亚细胞RNA组分分离和后续高通量测序分析，大量的RNA亚细胞定位信息被报道，利用这些数据并结合机器学习和深度学习的方...
Bioinformatics and Pharmacogenomics in Drug Discovery and Development
Bioinformatics Pharmacogenomics
2015/5/27
Objective: Literature review to evaluate the extent to which Bioinformatics has facilitated the drug discovery and development process from an economic perspective
Problem: A plethora of genomic and ...
Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
Microtubule Binding Associated Proteins
2015/5/26
Microtubules have many roles in the cytoskeletal infrastructure. This infrastructure underlies vital processes of cellular life such as motility, division, morphology, and intracellular organization a...
Application of Data Pipelining Technology in Cheminformatics and Bioinformatics
data pipelining technology cheminformatics bioinformatics
2015/5/26
Data pipelining is the processing, analysis, and mining of large volumes of data through a branching network of computational steps. A data pipelining system consists of a collection of modular comput...
Bioinformatics and Pharmacogenomics in Drug Discovery and Development- a Socio-economic Perspective
U.S Human Genome Project pharmacogenomics Socio-economic
2015/5/26
A plethora of genomic and proteomic information was uncovered by the U.S Human Genome Project (HGP) – mostly by means of bioinformatics tools and techniques. Despite the impact that bioinformatics and...
HAPPI: A Bioinformatics Database Platform Enabling Network Biology Studies
Database Genome Regulatory network
2015/5/26
The publication of the draft human genome consisting of 30,000 genes is merely the beginning of genome biology. A new way to understand the complexity and richness of molecular and cellular function o...
A Biological and Bioinformatics Ontology for Service Discovery and Data Integration
ontology language standard BACIIS SIBIOS bioinformatics
2015/5/26
This project addresses the need for an increased expressivity and robustness of ontologies already supporting BACIIS and SIBIOS, two systems for data and service integration in the life sciences. The ...
Bioinformatics and Pharmacogenomics in Drug Discovery and Development- a Socio-economic Perspective
bioinformatics drug development U.S Human Genome Project pharmacogenomics Socio-economic
2015/1/9
A plethora of genomic and proteomic information was uncovered by the U.S Human Genome Project (HGP) – mostly by means of bioinformatics tools and techniques. Despite the impact that bioinformatics and...
Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
Analysis proteins
2015/1/9
Microtubules have many roles in the cytoskeletal infrastructure. This infrastructure underlies vital processes of cellular life such as motility, division, morphology, and intracellular organization a...
Application of Data Pipelining Technology in Cheminformatics and Bioinformatics
data pipelining technology cheminformatics bioinformatics
2015/1/9
Data pipelining is the processing, analysis, and mining of large volumes of data through a branching network of computational steps. A data pipelining system consists of a collection of modular comput...
Bioinformatics analysis of metallothionein gene from Agaricus bisporus, Ganoderma lucidum, Taiwanofungus camphorates and Paxillus involutus
Metallothionein Gene Agaricus bisporus Ganoderma lucidum
2013/3/4
Metallothionein (MT) gene has an important role in the detoxification of toxic metals especially some heavy metals. Based on the published sequences of MT genes from Agaricus bisporus, Garnoderma luci...
Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology
Microarrays, reproducibility forensic bioinformatics
2010/10/19
High-throughput biological assays such as microarrays let us ask very detailed questions about how diseases operate, and promise to let us personalize therapy. Data processing, however, is often not d...
Cloning and Bioinformatics Analysis of TIR1 cDNA from Super Hybrid Rice Parental Line 1S
生长素受体 生物信息学 超级杂交水稻 TIR1
2009/11/18
生长素受体TIR1通过形成SCFTIR1复合体与生长素直接结合, 即为Aux/IAA在26S 蛋白酶体降解过程中的关键蛋白质。在Blas t检索和生物信息学分析的基础上设计特异引物, 以超级杂交水稻(Oryz a sativa)亲本株1S为材料, 通过RT-PCR扩增并经T-A克隆后测序, 获得一条长度为2 219 bp 的序列, 其开放阅读框长度为1 764 bp, 编码含587个氨基酸残基的肽...
Macromolecular Databases-A Background of Bioinformatics
macromolecular databases proteins nucleic acids
2009/3/19
Macromolecular Databases-A Background of Bioinformatics.
鸡催乳素基因序列多态及生物信息学分析Polymorphisms and Bioinformatics Analysis of Chicken Prolactin Gene
鸡催乳素（cPRL）基因 单核苷酸多态性（SNPs） 片段插入/缺失多态 生物信息学
2008/1/10
摘要
选择繁殖性能具有明显差异的4个鸡品种（莱航鸡、阳山鸡、丝羽乌骨鸡和隐性白洛克鸡）构建品种DNA池，采用测序的方法快速筛查鸡催乳素基因（chicken prolactin，cPRL）5′侧翼调控区、外显子区和部分内含子区约4500 bp范围内可能与产蛋性能相关的序列多态，共检测到13个SNPs和两个短片段（24 bp和15 bp）插入/缺失多态，其中在5′侧翼序列筛查到9个SNPs及两个短片...