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髓母细胞瘤是儿童最常见的颅脑恶性胚胎性肿瘤，世界范围的发病率为每年5.07-6.8/10万人，是引起儿童肿瘤相关死亡的首要原因。目前针对髓母细胞瘤的治疗是一种联合治疗的策略，手术为主，综合放疗以及化疗、靶向药物治疗等作为辅助治疗。髓母细胞瘤的发病机理极其复杂，涉及表观遗传学、胚胎发育学等多个方面，目前尚未完全明确，导致总体治疗效果并不是非常理想。
新型冠状病毒肺炎（COVID-19）已经成为人类有史以来影响面最广的感染性疾病，目前全球感染人数已超过一亿人，死亡病例已超过两百万人，并深刻的影响到了全世界。上海市免疫学研究所在新冠疫情爆发之初组建了新冠病毒的应急公关团队开展新冠免疫学相关的研究，并积极参与由北京大学张泽明教授牵头，我国四十多家医院大学和研究机构自发组建的“新冠肺炎单细胞研究中国联盟(Single Cell Consortium ...
2021年1月11日，上海交通大学医学院上海市免疫学研究所邹强团队联合邓刘福团队、上海交通大学医学院附属瑞金医院王正廷副主任医师团队在国际著名期刊Molecular Cell在线发表了题为“SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function”的研究论文。该研究发现...
Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture
Novel coronavirus alkaloid broad-spectrum antiviral 2019-nCoV SARS-CoV-2
2020/6/11
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined...
Multi-photon evanescent wave (MPEW) excited lanthanidedoped upconverting nanoparticles (UCNPs) for fast single particles tracking and live cell membrane imaging
biomedical optical imaging biomembranes cellular biophysics doping multiphoton processes nanomedicine nanoparticles optical tracking rare earth metals MPEW
2016/12/2
We propose a novel multi-photon evanescent wave (MPEW) excitation modality for upconverting nanoparticles (UCNPs) based microscopy. Experimental results show this new imaging method for UCNPs is nonsc...
Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I–IV in enterally fed rats
mitochondrial complexes I–IV electron transport chain rats
2016/6/13
Previous studies suggested that cell energetics are
altered by malnutrition.
Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n−3 or n−6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
Fish oil immunity natural killer cell
2016/6/12
Animal studies showed that dietary flaxseed oil
[rich in the n3 polyunsaturated fatty acid -linolenic acid
(ALA)], evening primrose oil [rich in the n6 polyunsaturated
fatty acid -linolenic acid (...
Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n−3 fatty acids
sudden cardiac death cardiac arrest ventricular arrhythmias
2016/6/1
Dietary intake of long-chain n23 polyunsaturated
fatty acids (PUFA) may protect against sudden cardiac
death, an event that may be predicted by measurement of heart
rate variability (HRV).
Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian women
Stable isotopes iron zinc
2016/5/30
We aimed to examine the influence of iron status on
iron absorption during pregnancy by measuring supplemental
iron absorption, red blood cell iron incorporation, and iron status
in pregnant women.
Serum and red blood cell folate concentrations, race, and education: findings from the third National Health and Nutrition Examination Survey
Education ethnic group folic acid
2016/5/30
Little is known about the relations between race or
ethnicity, educational attainment, and serum and red blood cell folate
concentrations.
Multifocal Skeletal Tuberculosis Mimicking Langerhans Cell Histiocytosis in a Child: a Case Report With a Long-Term Follow-Up
Tuberculosis Bone and Bones Spine
2015/12/29
Introduction: Multifocal skeletal tuberculosis is a rare condition that may masquerade as Langerhans cell histiocytosis, especially in children.
Small Cell Carcinoma of the Esophagus: Clinicopathological Features and Outcome of 22 Cases
Small Cell Carcinoma Esophagus Prognosis Surgical Procedures Chemotherapy
2015/11/9
Background: Small cell esophageal carcinoma (SCEC) is a highly aggressive and rare neoplasm.
Status of p53 and p27KIP1 in Iranian Patients With Oral Squamous Cell Carcinoma
Survival Squamous Cell Carcinoma Tumor Suppressor Protein p53
2015/11/9
Background: Alterations in p53 and p27KIP1 have been documented as important events in the carcinogenesis of various cancers, but their prognostic role in oral squamous cell carcinoma (OSCC) remains c...
Unusual Growth of Upper Lip Squamous Cell Carcinoma: A Case Report
Squamous Cell Carcinoma Skin Prognosis Pathology
2015/10/22
Introduction: Squamous cell carcinoma is the most common type of lip and oral cavity cancers. In majority of cases it follows quite common course, and after the surgery it does not produce any harm. T...
The Oncolytic Effect of Respiratory Syncytial Virus (RSV) in Human Skin Cancer Cell Line, A431
Oncolytic Viruses Apoptosis Skin Neoplasms Flow Cytometry
2015/9/29
Background: Oncolytic viruses have become of noticeable interest as a novel biological approach for selectively infecting cancer cells and triggering apoptosis in a number of malignant cells. Many res...