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南京大学医学院吴稚伟/吴喜林团队发现强效HIV纳米抗体（图）
HIV 纳米抗体 南京大学医学院
2024/8/23
近年来，抗逆转录病毒疗法（ART）在抑制HIV复制方面取得了显著进展，显著延长了艾滋病患者的寿命，但该疗法同时也带来了严重的副作用，并导致大量耐药病例的出现。CD4作为HIV进入宿主细胞的主要受体，一直是HIV药物研发的重点靶点。然而，目前唯一的CD4抗体药物在抑制HIV病毒的广谱性和效率上仍存在不足，长期应用会导致耐药性的产生。因此，探索更有效、更广谱的中和抗体成为当务之急。
研究发现不同趋化因子调控整合素α4β7与HIV-1病毒结合的新机制
趋化因子 HIV-1 整合素α4β7 病毒
2021/7/23
2021年，7月16日，《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy）在线发表了中国科学院分子细胞科学卓越创新中心研究员陈剑峰课题组和中科院大连化学物理研究所研究员李国辉、副研究员张跃斌团队合作完成的最新研究成果——Distinct chemokines selectively induce HIV-1 gp120-integrin α4...
Nearly 37 million people worldwide are living with HIV. When the virus destroys so many immune cells that the body can’t fight off infection, AIDS will develop. The disease took the lives of more than...
Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis
HIV AIDS Broadly Neutralizing Antibodies (bNAbs) Vectored Immunoprophylaxis
2013/1/30
Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been p...
Quantitative Computerized Tomography (QCT) versus Dual X-Ray Absorptiometry (DXA) in the Assessment of Bone Mineral Density of HIV-1 Infected Children
Bone Mineral Density HIV-Infected Children CT DXA
2013/2/19
Bone studies of HIV-infected children using dual X-ray absorptiometry (DXA) suggest bone mineral density (BMD) abnormalities. Pediatric studies are often performed using DXA instead of computed tomogr...
Optimized Antiretroviral Therapy with Darunavir/Ritonavir, Etravirine and/or Raltegarvir: A Salvage Therapy Option in HIV-1 Infected Patients with Long-Term Therapeutic Failures, about 23 Cases
Darunavir/Ritonavir Etravirine Raltegravir HIV-1
2013/2/19
Objectives: The aims of this study was to analyze the immuno-virologic response after optimised background antiretroviral therapy (OBT) associated to new active antiretroviral treatment (ART) in HIV-1...
The Role of Religiosity in HIV Prevention in Uganda: A Case-Control Study among Muslim and Christian Youth in Wakiso District
Religiosity HIV Prevention Muslim Christian Uganda Youth HIV-Risk Behaviors
2013/2/19
Background: In Uganda's HIV prevention strategy religious institutions are encouraged to deliver HIV prevention messages to the general public and to integrate HIV prevention into faith-based activiti...
Thyroid abnormalities have been reported in persons with HIV infection, although data have been inconsistent with respect to its frequency and association with specific medications. The purpose of thi...
Factors Associated with First-Line Antiretroviral Therapy Failure amongst HIV-Infected African Patients: A Case-Control Study
HIV Treatment ART Failure
2013/2/19
Background: Since 2001, anti-retroviral therapy (ART) has been provided to over 75,000 HIV-infected patients at the USAID-Academic Model Providing Access to Healthcare (AMPATH) Partnership in western ...
HIV prevention: Towards a “structural-plus” approach
HIV Prevention Structural Factors Development
2013/1/29
Lack of integration and coordination between HIV prevention programmes and developmental programmes explain why many countries have not been able to halt the epidemic, and others still have unacceptab...
The Detrimental Effect of Adversity on HIV Outcomes in the Era of Combined Anti-Retroviral Therapy
HIV Outcomes Psychosocial Adversity Adherence
2013/2/19
Socially disadvantaged individuals with HIV experience unacceptably high rates of AIDS and death. The authors developed an adversity index to quantify the impact of demographic and psychosocial factor...
Retention in HIV Care among Patients Testing Positive for HIV and Ineligible to Start Antiretroviral Therapy
Retention Attrition HIV Care Patients Nigeria
2013/2/19
Background: The failure to monitor and link patients from HIV testing to HIV care and retain them in care until they are eligible for ART is a major barrier to early ART initiation. This study evaluat...
Disclosing HIV to Infected Children in South Africa in the Era of HAART: A Grounded Theory Study on the Process, Reasons and Outcomes of Disclosure
HIV Infected Children Revealing the Diagnosis
2013/2/19
South Africa has seen an increasing population of children and adolescents accessing antiretroviral treatment (ART) in the past seven years. Many of these children are at the age when they should know...
Determinants of HIV/AIDS Awareness among Garments Workers in Dhaka City, Bangladesh
HIV/AIDS STDs Garments Workers in Bangladesh Logistic Regression Model
2013/2/19
The main purpose of this study is to find the awareness level as well as the determinants of awareness on HIV/AIDS among the garments workers in Dhaka City, Bangladesh. To do so, 200 garments workers ...
HDV-RNA and HBsAg Evolution during peg-IFN Treatment in Three HBV-HDV-HCV-HIV Coinfected Patients
Delta Hepatitis HIV Infection Interferon Treatment HDV Viral Load Quantitative HBsAg
2013/2/19
Background: Patients coinfected with HBV, HDV, HCV and HIV are usually excluded from clinical trials. Data on pegylated interferon treatment in this setting are limited, with predictive factors for HD...