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Cholesterol-metabolism study suggests new diagnostic, treatment approach for aggressive prostate cancer（图）
diagnostic prostate cancer
2014/3/20
WEST LAFAYETTE, Ind. - Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that cou...
Pituitary-testicular function of prostatic cancer patients during treatment with a gonadotropin-releasing hormone agonist analog. II. Endocrinology and histology of the testis
Pituitary-testicular function prostatic cancer patients gonadotropin-releasing hormone
2009/2/23
Endogenous testosterone (T), LH and FSH receptors, and in vitro production of cyclic adenosine-3':5'-monophosphate (cAMP), T and some of its steroid precursors were measured in testicular tissue obt...
Pituitary-testicular function of prostatic cancer patients during treatment with a gonadotropin-releasing hormone agonist analog. I. Circulating hormone levels
Pituitary-testicular function prostatic cancer patients treatment gonadotropin-releasing hormone
2009/2/23
Eight patients with advanced prostatic carcinoma (ages 59 to 78 years) were treated with a potent gonadotropin-releasing hormone (GnRH) agonist analog (buserelin, Hoechst; 600 micrograms intranasall...
Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells
Androgen receptor gene regulation
2009/2/17
We studied the response of the human ornithine decarboxylase (ODC) promoter to androgen in human prostate cancer cell lines. In the well-differentiated, androgen-sensitive human prostate cancer li...
Serum androgens：associations with prostate cancer risk and hair patterning
Prostatic neoplasms hormones testosterone baldness
2009/2/17
Cancer of the prostate is the leading cancer among American men, yet few risk factors have been established. Hair growth and development are influenced by androgens, and it has long been suspected...
Overview of enzyme inhibitors and anti-androgens in prostatic cancer
enzyme inhibitors anti-androgens prostatic cancer
2009/2/7
Surgical castration and estrogen therapy for prostate cancer were developed in 1941, and have been shown to improve both quality of life and survival. Little change in the therapeutics of prostate...
Response of circulating gonadotropin levels to GnRH agonist treatment in prostatic cancer
LH FSH testosterone bioactive LH buserelin
2009/2/7
Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) responses to 6-month treatments with a gonadotropin-releasing hormone (GnRH) agonist (buserelin) and subsequent orc...
Testicular pathology in 46,XY dysgenetic male pseudohermaphroditism：an approach to pathogenesis of testis cancer
Gonadal dysgenesis gonadotropins testicular carcinoma in situ
2008/12/29
Eleven children with dysgenic male pseudohermaphroditism (DMP) and 18 boys with isolated penile hypospadias, all with 46,XY karyotype, were studied. Testicular dysgenesis was associated with signifi...
Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft
Androgen receptor regulation G1 cyclin cyclin-dependent kinase CWR22 huma prostate cancer
2008/12/29
Human prostate cancer is initially dependent on androgens for growth, and androgen-dependent cells undergo apoptosis after castration. However, a subset of androgen-responsive cells survives and event...
Differential expression of CCAAT/enhancer-binding protein-delta（c/EBPdelta）in rat androgen-dependent tissues and human prostate cancer
CCAAT/enhancer-binding protein-delta（c/EBPdelta） rat androgen-dependent tissues human prostate cancer
2008/12/26
CCAAT/enhancer-binding protein delta (C/EBPdelta) is a nuclear transcription factor that regulates cellular growth and differentiation. In this study we demonstrate that C/EBPdelta gene expression i...
Biphasic Effect of Androgens on Prostate Cancer Cells and Its Correlation With Androgen Receptor Coactivator Dopa Decarboxylase
Neuroendocrine differentiation methyltoenolone cDNA microarray
2008/12/24
The aim of this study was to explore the mechanism underlying the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen r...
Sperm Cryopreservation：Recent and Marked Increase in Use for Testicular Cancer Compared With Hodgkin Disease
Sperm Cryopreservation Marked Increase Testicular Cancer Hodgkin Disease
2008/12/24
In a public network of sperm banks, time trends in use of sperm cryopreservation by men with testicular cancer (TC) and Hodgkin disease (HD) were assessed from 1990 to 2004. During this period, overal...
Effects of the Chemotherapy Cocktail Used to Treat Testicular Cancer on Sperm Chromatin Integrity
Sperm DNA DNA strand breaks
2008/12/24
The incidence of testicular cancer has increased dramatically over the past 50 years. Advances in treatment, which include the coadministration of bleomycin, etoposide, and cis-platinum (BEP),...
Metastatic Prostate Cancer After Orchiectomy, Radiotherapy, and Testosterone Replacement in a Patient With Bilateral Seminoma
Metastatic Prostate Cancer Orchiectomy Radiotherapy Testosterone Replacement Bilateral Seminoma
2008/12/24
Although its clinical benefits remain unproven and its indications controversial, the popularity of testosterone replacement therapy has grown substantially in recent years, in order to maintain v...
Circulating Inflammatory Cytokine Expression in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy
Hypogonadism inflammation
2008/12/24
Prostate cancer (PCa) is one of the most common cancers in men. Androgen deprivation therapy (ADT) is employed in the treatment of patients with metastatic or recurrent PCa, resulting in castrate le...