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HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer
Carcinoma Endometrioid HER2 Polymorphism Single Nucleotide
2015/9/29
Background: The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial.
PIK3CA基因突变的乳癌患者会对包括trastuzumab(Herceptin)和lapatinib (Tykerb)在内的常规HER2靶向治疗耐药。但根据在AACR上报道的对EMILIA研究的亚分析数据,FDA2月批准的乳癌新药trastuzumab emtansine (Kadcyla,TDM1)治疗乳癌的疗效并不受PIK3CA基因突变情况的影响。