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Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following three years of daily treatment
Bisphosphonates remodeling suppression
2014/12/4
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughne...
Short-courses of dexamethasone abolish bisphosphonate-induced reductions in bone toughness
zoledronic acid mechanical properties toughness remodeling suppression
2014/12/4
Atypical femoral fractures, which display characteristics of brittle material failure, have been associated with potent remodeling suppression drugs. Given the millions of individuals treated with thi...
Reference-Point Indentation Correlates with Bone Toughness Assessed Using Whole-Bone Traditional Mechanical Testing
bone mechanical testing material properties
2014/12/4
Traditional bone mechanical testing techniques require excised bone and destructive sample preparation. Recently, a cyclic-microindentation technique, reference-point indentation (RPI), was described ...