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Stem cell factor (SCF) mediated c-Kit signaling, and downstream activation of Phosphatidylinositol-3 Kinase (PI-3K) is critical for multiple biological effects mediated by mast cells. Mast cells expre...
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
Cutaneous mast cell tumor (MCT) shows a variable biological behavior in dogs and may present either as solitary masse that can be treated and cured with surgical removal or as a systemic metastatic an...
Objective: To collect high quality, representative tissue material from tumors and manage its distribution to different laboratories. Design: Prospective controlled study. Animals: Thirty-six dogs wit...
Background: Wound healing is a complicated and integrated process. Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabet...
Background: Squamous cell carcinoma (SCC) is the most common malignancy in the oral cavity. Angiogenesis is essential for development and progression of SCC. Recently, some studies have reported that ...
Background: Ag-dependent activation of IgE-bearing mast cells is a critical first step in immediate hypersensitivity and other allergic responses. Recent studies have revealed Ag-independent effects o...
The MC lineage seems to be far from the granulocyte lineages including basophils. CMA1-high MCs (MCTC) and CMA1-low MCs (MCT) can be regarded as differentiated MC subtypes. As such, importance of data...
To investigate the possible involvement of cytoskeletal components in antigen (Ag)-mediated activation of phospholipase D (PLD) in rat basophilic leukemia (RBL-2H3) cells, the effects of cytochalasin ...
Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of al...
Mast cells in the allergic nasal mucosa are reported to have higher concentrations of high affinity type I Fcε receptors (FcεRI) than mast cells in the non-allergic mucosa. IgE binds to FcεRI on mast ...
Stimulation of mast cells induced the elevation of intracellular cytosolic free Ca2+ concentrations ([Ca2+]i) and the translocation of protein kinase C (PKC) from the cytosol to the cell membrane, fol...
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...

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