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心脑血管疾病(CVD)是全世界人口死亡的主要原因之一。85%的CVD相关死亡是由于心脏病发作和脑中风导致。动脉粥样硬化引发动脉管腔狭窄导致心脏病发作和脑中风。前期,中国科学院遗传与发育生物学研究所张永清研究员团队与北京希诺谷生物技术公司和首都医科大学吉训明教授等团队合作在SCIENCE CHINA Life Sciences发表了Dogs lacking Apolipoprotein E show...
The DNA in our cells constantly changes its structure and chemical composition in the course of endogenous processes and in response to exogenous challenges. The 2017 Mammalian DNA Repair GRC will exp...
The mammalian lignans enterolactone and enterodiol are produced in the colon by the action of bacteria on the plant precursor secoisolariciresinol diglycoside, which is found in high concentrations...
Omega-3 polyunsaturated fatty acids (N-3) are essential nutrients for human health and integral components of neural tissues. There is evidence that N-3 supplementation may benefit exercise performanc...
Human apurinic/apyrimidinic endonuclease (hApe1) encodes two important functional activities: an essential base excision repair (BER) activity and a redox activity that regulates expression of a numbe...
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
Hydrostatic pressure and mammalian cardiac-pacemaker function.
In the present work the pressures necessary to fracture the semicircular canal of the mammalian inner ear, specifically the squirrel monkey, have been investigated experimentally. The results indicate...
Pyk-2 is a protein tyrosine kinase, highly expressed in human hippocampus, dentate gyrus and olfactory bulb. In this study, polyclonal antibodies against the C-terminal of pyk-2, starting from Pro-759...
Mammalian tissues, including heart, lung, liver, kidney, spleen, and skeletal muscle of guinea pig, rat, or pig, were exposed to tritium (T2) and high pressures of H2. Incorporation of the tritium lab...
We combined 'in situ' high pressure microscopy with confocal laser scanning microscopy to directly study Ca2+ homeostasis in intact mammalian (murine) skeletal muscle fibres during high pressure expos...
Selenium (Se) is an essential trace element of mammals and plays important roles in the form of selenocysteine residues in selenoproteins. Selenocysteine lyase (SCL) specifically catalyzes the decompo...
Selenocysteine lyase (SCL), which specifically catalyzes the decomposition of L-selenocysteine into Se and L-alanine, is proposed to function as a Se delivery protein to selenophosphate synthetase in ...
Mammalian tissues, including heart, lung, liver, kidney, spleen, and skeletal muscle of guinea pig, rat, or pig, were exposed to tritium (T2) and high pressures of H2. Incorporation of the tritium lab...

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