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Leptin is a peptide that is strongly correlated with adiposity and is a potential determinant of obesity and its complications.
Since first reported less than a decade ago (1), leptin has been a topic of considerable study. The variation in serum or plasma leptin concentrations has been described according to sex, age, measu...
Although it is known that plasma leptin concentrations correlate with the amount of adipose tissue in the body, little information is available on the long-term effects on leptin concentrations of ...
Plasma leptin in humans is subject to both longand short-term regulation; it correlates with indexes of body fat that can only change slowly. However, short-term fasting causes large and rapid decr...
During the past 2 y the leptin field has continued to expand rapidly (from 600 to >2000 citations currently in the MEDLINE database), extending leptin biology into areas well beyond feeding behavior a...
Little is known about the effects of physical training on plasma leptin concentrations in children.
Leptin is known to be cleared by the kidney, a tissue with substantial leptin receptor mRNA expression; however, lung, liver, and muscle tissues also express leptin receptor messenger RNA and it is...
Background: Leptin is secreted by adipose tissue and decreases appetite. However, the role of leptin in the pathogenesis of hemodialysis (HD)-related malnutrition has not been fully evaluated.
Background: There is some evidence suggesting that leptin and its negative regulator, soluble-leptinreceptor (SLR) may be able to influence inflammatory and autoimmune processes.
探讨瘦素(leptin)对人脑胶质瘤U87MG细胞迁移及侵袭能力的影响及其机制。方法:Leptin处理U87MG细胞,采用细胞划痕实验检测U87MG细胞的迁移能力,Transwell实验检测U87MG细胞的侵袭能力,RT-PCR及Western blotting法检测U87MG细胞中MMP-2及MMP-9 mRNA和蛋白的表达。结果:Leptin明显促进U87MG细胞迁移能力\[(152.42±3...
To investigate the effect of leptin treatment on circulating inflammatory cytokines and on tissue damage in experimental rat model of gram-negative sepsis. Materials and methods: Adult male Wistar rat...
Background: Leptin is an adipocyte- derived hormone that plays an important role in the pathogenesis of obesity. Obesity is associated with insulin resistance and hyperinsulinemia. Insulin resistance ...
Leptin is a 16-kD protein which is secreted from white adipocytes and, its discovery has generated enormous interest in the regulation of energy balance. Leptin has been implicated in the regulation o...
目的: 探讨HCC患者血清Lep, VEGF和AFP表达的临床意义. 方法: 用ELISA检测30例健康对照、31例肝硬化和146例HCC患者血清Lep, VEGF和AFP含量, 分析Lep, VEGF和AFP及其联合检测对HCC的诊断、临床分期和预后的意义. 结果: HCC患者血清Lep水平与BMI显著相关(r = 0.64, P<0.01), 且显著低于肝硬化组/健康对照组(19 mug/L ...

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