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缺血性卒中具有高发病率、高致死致残率等特点,其致病机制错综复杂,临床上防治困难,严重危害我国居民健康。阐明致病机理,对缺血神经多靶点保护、减轻“缺血瀑布”反应是未来研究神经保护药物的关键。近些年研究发现,小细胞外囊泡(small extracellular vesicles, sEVs)具有细胞主动分泌、携带蛋白质和核酸信息、在细胞之间进行信息传递的特性,不仅参与了多种疾病的发生发展进程,还因其能...
关节软骨缺损是最常见的骨科疾病之一,可引起关节功能障碍、严重疼痛和残疾,给患者个人和社会带来沉重的经济负担。不幸的是,由于软骨无神经无血管的特性,软骨缺乏自愈能力,因此关节软骨的再生仍然是一个相当大的挑战。组织工程通过理想的种子细胞、合适的生物材料和生物活性分子的结合,被认为是一种很有前途的软骨修复方法。
近日,北京友谊医院骨科中心唐海教授团队与北京邦塞科技有限公司合作在Bioactive Materials发表题为“Translation of a spinal bone cement product from bench to bedside”的研究论文。
创伤性脊髓损伤可导致脊髓组织缺损,损伤处的恶劣微环境给脊髓组织的再生以及移植细胞的存活带来巨大挑战。从在脊髓损伤处移植胚胎脊髓组织起至今近三十多年来,通过其中的胚胎脊髓神经元去替换死亡的脊髓神经元,在损伤/移植处形成神经元中继器(neuronal relay)修复脊髓损伤的理念逐渐形成,并得到了验证。然而,胚胎脊髓组织移植受到伦理学限制、移植物不易获取等多方限制,不符合临床转化的要求。如何有效地在...
Heart attacks provoke an acute immune response. Leukocytes rush to the heart muscle to remove dead cells and begin building scar tissue. This is followed by a second immune response, the resolving pha...
Because nuts have favorable fatty acid and nutrient profiles, there is growing interest in evaluating their role in a heart-healthy diet. Nuts are low in saturated fatty acids and high in monounsat...
The consumption of beverages containing caffeine and taurine before exercising has been associated with increased physical and psychological performances and has been promoted to support the emotional...
Tetraethyl orthosilicate (TEOS) and trimethyl orthosilicate (TMOS) alkoxysilanes are expensive common precursors for silicate based solgel derived bioactive glasses. Facile approa- ches involving low ...
Surgery on the skeleton frequently requires harvesting of autogenous bone graft from the pelvis, but this procedure is complicated by problems. The purpose of this retrospective, comparative descripti...
Objective: Bioactive glass is often used as a filler material for repair of dental bone defects.In different studies osteogenic potential of this material was proved, but its dentinogenesis property ...
This study investigated, both histologically and histometrically, the efficacy of enamel matrix derived proteins (EMD) associated with bioactive glass (BG) and an absorbable membrane in the treatment ...
Reconstruction of segmental mandibular defects resulting from trauma, tumor resection, and congenital defects is a significant challenge. The ability to design scaffolds to fill complex anatomic defec...
We developed a novel apatite coating method that consisted of two-step of chemical treatment: a combined pretreatment of concentrated acid etching and alkaline treatment, followed by alternate soaking...
Synthetic biomaterials hold the promise for engineering structures that enable controlled release of therapeutic drugs to targeted cells and organs and even cells for use in cell therapy and regenerat...
Introduction: In spite of multiple applications of bioactive glasses, these materials have not been evaluated yet for ridge augmentation. Due to the large number of patients who need ridge augmentat...

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