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Duodenal and ileal glucose infusions differentially alter gastrointestinal peptides, appetite response, and food intake: a tube feeding study
glucose appetite food intake brake ileum duodenum GLP-1 PYY ghrelin
2018/11/16
Background: Activation of the ileal brake through the delivery of nutrients into the distal small intestine to promote satiety and suppress food intake provides a new target for weight loss. Evidence ...
Carp proteins as a source of bioactive peptides–an in silico approach
biological activity bioinformatics BIOPEP fish databases proteolysis
2016/5/11
In silico prediction methods and tools were used to determine whether bioactive peptides are hidden in the amino acid sequences of carp (Cyprinus carpio) proteins and whether they can be released afte...
Synthetic Mimics Of Antimicrobial Peptides From Aryl Scaffolds
Pure sciences Amphiphilicity Antimicrobial peptides Immunomodulatory Smamps Suzuki coupling
2014/11/21
The rise in bacterial resistance and the declining approval rate of novel anti-infective drugs are a major threat to global public health. Antimicrobial peptides (AMPs), found in almost every multicel...
Optimization of Hydrolysis Conditions for Iron Binding Peptides Production from Shrimp Processing Byproducts
Iron Binding Peptides Production Hydrolysis
2016/6/2
Iron is one of the most popular trace elements in body and plays very important role in metabolism or construction of body. Organic iron from various sources for curing iron-deficiency anemia was one ...
超声波预处理对燕麦蛋白制备ACE抑制肽的影响(Effect of Oat-seed Protein Pretreatment by Ultrasonic on Preparation of ACE Inhibitory Peptides)
燕麦蛋白 ACE抑制肽 超声波
2010/12/29
利用燕麦蛋白制备ACE抑制肽时先利用超声波对燕麦蛋白原料进行预处理研究。以ACE抑制活性和水解度为指标,考察了超声波功率、处理时间、超声波工作/间歇时间对燕麦蛋白预处理效果的影响。结果表明,超声波预处理的最佳工艺参数为:超声波功率500W,处理时间20min,超声波工作时间2 s、间歇时间2 s,该条件下酶解产物对ACE的半抑制浓度IC50值从0.533mg/mL降到0.299mg/mL...
蛋清肽酶解工艺及血管紧张素转化酶抑制活性研究(Enzymatic Hydrolysis Technology for ACE-inhibitory Peptides from Egg White)
蛋清 ACE抑制肽 酶解
2010/12/29
采用酶法制备蛋清肽,色谱纯化ACE抑制活性组分并鉴定其一级结构。通过考察底物质量分数、加酶量、酶解温度和pH值对水解度的影响,结合多元线性回归设计和二次回归正交组合设计建立蛋清ACE抑制肽酶解工艺模型,并经液相色谱串联质谱鉴定其一级结构。结果表明:最佳酶解工艺为底物质量分数8%、pH值10.73、加酶量12.14%及酶解温度56.80℃,酶解物纯化后半抑制质量浓度为0.18mg/mL。液相色谱串...
Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation
proteins ACE inhibitors BIOPEP database in silico methods biological activity functional food
2010/3/24
This paper presents a modern in silico approach useful in the evaluation of proteins as a source of ACE inhibitors. All protein sequences analyzed were derived from the BIOPEP database. To determine t...
Online Programs and Databases of Peptides and Proteolytic Enzymes – A Brief Update for 2007–2008
peptides peptidomics proteolysis bioinformatics computer databases world wide web
2010/3/24
Bioinformatics methods have become one of the most important tools in peptide science. The number of available peptide databases is growing rapidly. The number of online programs able to process pepti...
Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Gnfola frondosa)
Grifola frondosa ACE inhibitor bioactive compound
2009/7/8
Three peptides which inhibit angiotensin I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them, Lys-Tyr-Thr-Phe-Ala-Val-Thr-Thr-Val-Lys-Thr-Trp...
Antioxidative Activity of Peptides Prepared from Okara Protein
antioxidative activity amino acid peptide
2009/6/17
Protease hydrolyses of an Okara protein yielded antioxidative activity against the peroxidation of linoleic acid in an aqueous system at pH 7.0. Four antioxidative peptides were isolated from the hydr...
Isolation and Characterization of Peptides with Antioxidant Activity Derived from Wheat Gluten
wheat gluten hydrolysate peptide
2009/6/17
Peptides having potent antioxidant activity were separated from the hydrolysate of wheat gluten by ion-exchange and gel filtration chromatography. Peptides obtained by SP Sephadex C-25 chromatography ...
Preparation of Angiotensin I-Converting Enzyme Inhibiting Peptides from Soybean Protein by Enzymatic Hydrolysis
soybean protein peptides angiotensin I-converting enzyme
2009/6/17
Soybean protein isolate was hydrolyzed using two proteases (Protease M and Orientase 90N), and the inhibitory activity of angiotensin I-converting enzyme (ACE) and bitterness of the hydrolysates were ...
Isolation and Properties of Antioxidative Peptides from Water-Soluble Royal Jelly Protein Hydrolysate
antioxidative peptide royal jelly protein hydrolysate
2009/6/10
Several novel antioxidative peptides from the hydrolysate of water-soluble royal jelly protein (WSRJP) were isolated, identified, and characterized. WSRJP was extracted from royal jelly and hydrolyzed...
Bitter-Tasting Sake Peptides Derived from the N-Terminus of the Rice Glutelin Acidic Subunit
bitter peptide sake rice glutelin
2009/5/20
Five bitter-tasting peptides were isolated from charcoal-untreated sake, following a Sepabeads resin separation, an initial reverse-phase chromatography (RP-HPLC), a gel permeation-chromatography, and...
Artificial Neural Network for Production of Antioxidant Peptides Derived from Bighead Carp Muscles with Alcalase
antioxidant peptides artificial neural network (ANN) bighead carp
2009/3/10
Controlled enzymatic modification proteins are currently being used as good sources of bioactive protein ingredients, and hydrolysates derived from bighead carp muscles may serve as antioxidants throu...