搜索结果: 1-15 共查到“基因工程 Protein”相关记录15条 . 查询时间(0.11 秒)
How DNA protein machines collide head on and stop replication（图）
DNA protein machines collide head on stop replication
2017/9/5
A new study describes how head-on collisions between protein machines on chromosomes can disrupt DNA replication and boost the rate of gene mutations that help bacteria survive hostile environments, r...
Enhanced tolerance to low-K+ stress in tobacco plants, that ectopically express the CBL-interacting protein kinase CIPK23 gene
low-K+ tolerance potassium tobacco
2016/7/6
Tobacco (Nicotiana tabacum) has a relatively high requirement for potassium (K+). However, the molecular basis of tolerance to low-K+ stresses in tobacco still remains unknown. Here, we report the rol...
The influence of the Ku80 carboxy-terminus on activation of the DNA-dependent protein kinase and DNA repair is dependent on the structure of DNA cofactors
DNA-PK Ku70/80 Ku80 Carboxy Terminus
2015/5/25
In mammalian cells DNA double strand breaks (DSBs) are highly variable with respect to sequence and structure all of which are recognized by the DNA- dependent protein kinase (DNA-PK), a critical comp...
The integrated stress response directs cell fate decisions in response to perturbations in protein homeostasis
diabetes cancer
2015/5/25
Disruptions of the endoplasmic reticulum (ER) cause perturbations in protein folding and result in a cellular condition known as ER stress. ER stress and the accumulation of unfolded protein activate ...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer
Breast Cancer Tissue Microarray Splice Variant Gene Expression
2014/12/12
Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer.
Characterization Of The Zebrafish Umleitung (uml) Mutant: Essential Roles For The Transmembrane Protein Brother Of Cdo (Boc) In Regulating Hedgehog (Hh) Mediated Cell Differentiation And Neural Patterning
Biological sciences Axon guidance Hedgehog signaling Morphogen gradients Neural patterning Pituitary
2014/12/10
The secreted Hedgehog (Hh) molecule acts as a morphogen, mitogen, and cell survival factor during embryogenesis and during later growth and tissue homeostasis periods in vertebrates. Hh plays these di...
黄鳝性腺高表达的核糖体蛋白基因Rribosomal Protein Genes Highly Expressed in Swamp Eel Gonads
核糖体蛋白 黄鳝 性别决定
2008/1/10
摘要
采用高密点阵技术从黄鳝雄性性腺cDNA文库中获得8个克隆，序列分析和BLAST结果显示它们编码的蛋白质分别与40S核糖体蛋白S4,S9,S16,S17,S20和60S核糖体蛋白L7, L18a,L29高度同源。 根据黄鳝RP蛋白序列和其他物种的相应同源序列构建ML系统发生树，显示核糖体蛋白基因在进化中高度保守。核糖体蛋白基因不仅可作为分子进化分析的有利工具，而且从它们的表达模式显示RP基因...
水稻胞质核糖体蛋白基因OsRPS7的克隆与序列分析Molecular Cloning and Sequece Analyzing of Cytoplasmic Ribosomal Protein Gene OsRPS7 From Rice ( Oryza sativa)
水稻 核糖体蛋白S7 基因克隆 基因结构
2008/1/10
摘要以已公布的黑麦胞质核糖体蛋白基因ScRPS7的cDNA序列为信息探针，在中国华大水稻基因组数据库中搜索与之高度同源的基因组重叠群。采用计算机拼接和RT-PCR方法克隆了水稻胞质核糖体蛋白基因的全长cDNA序列，命名为OsRPS7。该cDNA序列全长919bp，编码192个氨基酸；其与黑麦、拟南芥和芸薹的S7核糖体蛋白的氨基酸一致率分别为88%、72%和72%。对OsRPS7 的基因组结构和基因...
奇异果甜蛋白及其基因工程 Sweet Protein Thaumatin and It′s Genetic Engineering
甜味蛋白 奇异果甜蛋白 甜味机理 生理功能 基因工程
2007/12/30
摘要奇异果甜蛋白(thaumatin)是迄今为止最甜的物质之一，对其研究具有很重要的意义。奇异果甜蛋白的生化性质基本清楚，基因序列和氨基酸序列都已测定。它的甜味可能是由奇异果甜蛋白上特定基团和受体结合引起的。对奇异果甜蛋白的生理功能知之甚少。近二十年来，在奇异果甜蛋白的基因工程上取得了一定进展，但仍然存在许多困难。
Abstract:Thaumatin is one of the sweetes...
胃癌中APC基因I1307K突变及蛋白质表达The I1307K Mutation and Protein Expression of APC Gene in Gastric Cancer
APC基因 I1307K突变 蛋白质 胃癌
2007/12/30
摘要为探讨肿瘤抑制基因APC结构及表达异常与胃癌发生、发展的关系,采用ARMS PCR检测胃癌中APC基因I1307K突变存在与否，免疫组织化学方法分析胃癌中APC蛋白表达水平。结果表明，在 62例胃癌高发区易感人群血液标本及45例胃癌中未检测到I1307K突变；胃癌（早期、进展期）中APC蛋白表达阳性率显著低于正常黏膜，进展期胃癌中APC蛋白表达阳性率显著低于早期胃癌，淋巴结转移阳性的胃癌中AP...
阿尔茨海默病中β淀粉样前体蛋白基因外显子9、10的mRNA表达及突变研究--Expression Variation and Mutation Analysis of Exon 9 and 10 in Amyloid Precursor Protein Gene in Alzheimer′s Disease
阿尔茨海默病 β淀粉样前体蛋白基因 表达 突变
2007/12/5
于上海地区汉人群中，探讨阿尔茨海默病(AD)患者外周血中β淀粉样前体蛋白基因外显子9、10（APP9~10）的mRNA表达水平，并作cDNA的点突变检测。采用半定量竞争性反转录聚合酶链反应(semi-quantitive competitive RT-PCR)技术测定APP9~10的mRNA表达水平；以聚合酶链反应（PCR）-限制性片段长度多态(RFLP)方法检测基因组DNA中载脂蛋白E基因(AP...
专著信息
书名
Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65.
语种
英文
撰写或编译
作者
Yi H,Rong Y...
专著信息
书名
DNA microarrays with unimolecular hairpin double-stranded DNA probes: fabrication and exploration of sequence-specific DNA/protein interactions.
语种
英文
撰写或编译
作者
Jinke Wang,Yunfei Bai,Tongxiang ...
专著信息
书名
Fabrication of double-stranded DNA microarray on solid surface for studying DNA-protein interactions: a high-throughput platform for profiling bimolecular interaction.
语种
英文
撰写或编译
作者
Jinke Wan...