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Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-kappa B mediated acute lung inflammation in mice
Electronic cigarette aerosol Acute lung inflammation Oxidative stress NF-κ b pathway Aldehyde
2023/6/21
Electronic cigarette (e-cigarette) use has been linked to recent acute lung injury case clusters in over 2000 patients and dozens of deaths in the United States, however, the mechanism leading to lung...
2017 细胞死亡和炎症 Keystone Symposia （2017 Keystone Symposia on Cell Death and Inflammation）
2017细胞死亡和炎症Keystone Symposia
2017/3/10
Cell death has long been known to be an important instigator of inflammation in sterile injury, as well as an amplifying factor in infection-associated inflammation, but the specific molecules underpi...
An IL-4-dependent macrophage-iNKT cell circuit resolves sterile inflammation and is defective in mice with chronic granulomatous disease
macrophage-iNKT cel chronic granulomatous disease
2015/5/21
The immune system initiates tissue repair following injury. In response to sterile tissue injury, neutrophils infiltrate the tissue to remove tissue debris and subsequently undergo apoptosis. Proper c...
Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
cells microRNAs eosinophilic esophagitis asthma
2015/5/21
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational ...
Mitochondria nitric oxide synthase in inflammation and septic shock
septic shock inflammation Mitochondria nitric oxide synthase
2014/3/31
NO can be quantitatively measured via its reaction with HbO2 to form metHb, which can be detected as an increase in the OD at 401nm. Fig showed the formation of NO by submitochondrial particles, which...
PAK1's regulation of eosinophil migration and implications for asthmatic inflammation
airway inflammation p-21 activated kinase 1 (PAK1) chemotaxis
2015/5/21
More than 300 million people world-wide suffer from breathlessness, wheezing, chest tightness, and coughing characteristic of chronic bronchial asthma, the global incidence of which is on the rise. Al...