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Gordon Research Conference on Notch Signaling in Development, Regeneration & Disease
Regeneration Disease
2016/7/29
The 2016 Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease will provide a stimulating forum to discuss and disseminate new research, concepts and therapeutic oppor...
The role of notch signaling in regulating nuclear hormone receptor activity in mammalian T lymphocytes and Drosophila
Programmed cell homeostasis biological and nuclear hormone receptors and signaling pathways programmed cell death lymphocytes drosophila melanogaster model system
2015/1/28
Regulation of programmed cell death is crucial for proper development and maintaining homeostasis of organisms. This thesis work attempts to elucidate the relationships between two evolutionarily well...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...