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清华大学施一公研究组发文报道人体γ-分泌酶与重要底物Notch和APP复合物的高分辨率三维结构（图）
清华大学 施一公 人体γ-分泌酶 Notch APP复合物 高分辨率 三维结构
2019/1/12
2018年12月31日和2019年1月10日，施一公教授领导的研究团队在《自然》（Nature）和《科学》（Science）分别发表了《人源γ-分泌酶识别底物Notch的结构机制》（Structural basis of Notch recognition by human γ-secretase）和《人源γ-分泌酶底物淀粉样前体蛋白的识别》（Recognition of amyloid prec...
Gordon Research Conference on Notch Signaling in Development, Regeneration & Disease
Regeneration Disease
2016/7/29
The 2016 Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease will provide a stimulating forum to discuss and disseminate new research, concepts and therapeutic oppor...
2016年1月7日，国际学术期刊Scientific Reports 在线发表了中国科学院上海生命科学研究院生物化学与细胞生物学研究所赵允研究组题为Chi and dLMO functionantagonistically on Notch signaling through directly regulation of fng transcription 的研究论文。该研究揭...
The role of notch signaling in regulating nuclear hormone receptor activity in mammalian T lymphocytes and Drosophila
Programmed cell homeostasis biological and nuclear hormone receptors and signaling pathways programmed cell death lymphocytes drosophila melanogaster model system
2015/1/28
Regulation of programmed cell death is crucial for proper development and maintaining homeostasis of organisms. This thesis work attempts to elucidate the relationships between two evolutionarily well...
The role of Notch in T cell activation and development
To activate T cells incision p53 intracellular domain HES1 genes
2014/12/11
Notch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP) to CD8 + single positive (SP) transition, but regulation of Notch activation is not well underst...
Notch-1 regulates IFN-gamma secretion through activation of NF-kappaB
An immune response cell factor cell differentiation T cells activate T cell line
2014/12/11
The cytokine IFN-γ is important in mediating immune responses, while the Notch family of transmembrane receptors has been implicated in modulating T cell differentiation at several stages of developme...
Notch functions from the cytoplasm to the nucleus during T cell activation
Cytokines T cells activate cells cell signal
2014/12/11
Notch1 specifically upregulates expression of the cytokine interferon-γ in peripheral T cells through activation of NF-κB. However, how Notch mediates NF-κB activation remains unclear. NF-κB activatio...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
Notch 1 Mediated Inhibition of Nur77-induced apoptosis: Implications for T-cell Leukemia
Apoptosis Calcium IP3R Leukemia Notch1 Nur77
2014/12/10
It is widely accepted that activating mutations of genes encoding the Notch family of transmembrane receptors, specifically Notch1, are associated with oncogenic transformation. Previous data from our...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
中国医科大学生物技术课件第十章 Wnt与Notch信号转导
中国医科大学 生物技术 课件 第十章 Wnt与Notch信号转导
2014/9/12
中国医科大学生物技术课件第十章 Wnt与Notch信号转导。
Notch信号通路对干细胞分化的影响
Notch通路 干细胞 分化
2012/7/17
干细胞的增殖分化受到自身或外在、远程或近程多种信号通路的调控， 而细胞之间的相互通讯在此过程中起到重要作用。Notch通路就是通过相邻细胞之间相互通讯调控细胞分化的重要信号通路之一， 众多研究显示， 该通路的活化在干细胞分化过程中发挥了重要调节作用， 本文就此相关研究进展作一简要综述。
大鼠Notch 1胞质段的克隆及其表达
Notch 胞质段 克隆 表达
2008/9/24
Notch 1信号途径参与决定细胞命运，其水解后产生的活性片段——胞质段（Notch 1 intracellular cytoplasmic domain, NICD）能被转运进核，激活下游靶基因的表达.Notch 1参与细胞的增殖、分化、程序性死亡、发育过程中的形态发生和器官形成等许多重要过程.为了获得重组的NICD，以大鼠脑cDNA文库为模板，用PCR方法扩增出编码NICD的基因片段，克隆至谷...
A notch structure on the Moho beneath the Eastern San Gabriel Mountains
Moho depth receiver functions San Andreas Fault San Gabriel Fault Pelona Schist San Gabriel Mountains
2014/4/10
Synthetic waveform modeling of the anomalous receiver functions for two stations in the eastern San Gabriel Mountains, California, suggests that a flat-topped notch structure exists on the Moho. North...