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中国科学院武汉病毒研究所揭示新型CRISPR-Cas系统的分子机制（图）
免疫,基因,病毒
2024/8/19
2024年8月19日，中国科学院武汉病毒研究所邓增钦团队与天津医科大学基础医学院张恒团队合作，在《自然》（Nature）上发表了题为Structural basis for the activity of the type VII CRISPR-Cas system的研究论文。该研究证实了VII型CRISPR-Cas系统能够特异性识别细胞内转录本并靶向敲低基因表达，并能够帮助宿主菌抵抗噬菌体的感染...
中国科学院动物研究所专利：工程化的Cas效应蛋白及其使用方法
中国科学院动物研究所 专利 工程化 Cas效应蛋白
2024/5/30
本文提供了用于工程化改造酶诸如Cas核酸酶以增加其酶活性的方法。还提供了工程化的Cas效应蛋白，包括工程化的Cas12b、Cas12i和Cas9核酸酶及其衍生物，以及其使用方法。
耦合模式对于年平均赤道太平洋海表温度的模拟有着很大的偏差，主要体现在赤道中太平洋和西太平洋的冷偏差以及赤道东太平洋的暖偏差。尽管随着模式的发展，赤道太平洋海表温度的模拟有了一定改进，CMIP6模式集合平均历史实验（HIST）的结果表明偏差依旧显著存在。 CAS-ESM2-0作为参与了CMIP6的耦合模式，其历史实验（HIST）结果在赤道太平洋海表温度的模拟偏差和CMIP6模式集合平均的模拟偏差类似...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：基于stPCA降维算法的ICU病人出院策略法
stPCA降维算法 ICU病人 出院策略法
2023/12/11
许多复杂生物系统可以由高维非线性动力系统描述，对原始数据进行降维有助于对这些系统进行有效分析。然而以一种可解释的方式进行极致低尺度的降维仍然是一个具有挑战性的问题。基于Takens延迟嵌入理论，将高维空间信息转换为低维时间信息，我们开发了极致低降维算法stPCA，并将其应用于重症监护医疗信息管理系统MIMIC-III和MIMIC-IV数据集，提出了ICU病人的出院决策。stPCA基于ICU患者的高...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Occupation fields for Markov loops
马尔可夫循环 占用域 格林函数
2023/11/29
In this talk, we introduce occupation fields for vertices and oriented edges and compute their distributions. More precisely, under the Markov loop measure, the expected number for crossings of an ori...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Nonlinear potentials at the fractional scale:sharp regularity
分数尺度 非线性势 尖锐 正则性
2023/11/29
Nonlinear potential theory and elliptic regularity theory are two classical topics in the modern analysis of partial differential equations. In this talk I show how these themes merge to solve the lon...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Adaptive stabilization of non-cooperative stochastic differential games
非合作 随机微分对策 自适应镇定
2023/11/29
We considers the adaptive stabilization problem for a basic class of linear-quadratic non-cooperative stochastic differential games when the systems matrices are unknown to the regulator and the playe...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars："Sobolev extensions"(7)&(8)
Sobolev扩展 Whitney扩展 技术变体
2023/11/29
I will give an introduction to Sobolev extensions, including the use of variants of the Whitney extension technique. I will concentrate on the basics of the theory.
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Kerr-Newman型时空中Majorana费米子的存在性问题
Kerr-Newman型时空 Majorana费米子 存在性
2023/11/29
Dirac方程最初是Dirac为解决Minkowski时空中Klein—Gordon方程的粒子的负几率与负能问题建立的。1980年，Weinberg和Witten证明了引力无法量子化，所以为了将引力引入量子场论中，数学和物理学家将平直时空的Dirac方程推广到弯曲时空的Dirac方程，弯曲时空Dirac方程表示了任一自由费米子物质场在时空背景所应满足的场方程，是宇宙学研究的核心问题。2000年Fi...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Laplacian estimates for the cscK equation
cscK方程 拉普拉斯估计 Nash-Moser迭代
2023/11/29
We will report Chen-Cheng’s work on cscK equations. We derive the Laplacian bound using Nash-Moser iteration.
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Random phase approximation for the mean-field electron gas （3）
平均场 电子气 随机相位近似
2023/11/29
Random phase approximation (RPA) was proposed by Bohm and Pines in four seminal papers during 1951-1953 to describe the correlation of fermions, namely the correction to the Hartree-Fock theory. While...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Analytic smoothing effect of a class of ultra-parabolic equations
一类超抛物型方程 解析 光滑效应
2023/11/29
We study a class of ultra-parabolic equations, it is a high order degenerate parabolic operators of Hormander type, so it is strongly degenerate, but we prove that this class operators possesses the a...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars："Inverse problems for elliptic PDE" (8)
椭圆偏微分方程 反问题 Calderón问题
2023/11/29
This course will give an introduction to inverse problems for elliptic partial differential equations. The most famous example of such problems is the Calderón problem, which arises in seismic and med...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars："Inverse problems for elliptic PDE" (7)
椭圆偏微分方程 反问题 Calderón问题
2023/11/29
This course will give an introduction to inverse problems for elliptic partial differential equations. The most famous example of such problems is the Calderón problem, which arises in seismic and med...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Functions of bounded variation and nonlocal functionals
有界 变差函数 非局部泛函
2023/11/29
In the past two decades, starting with the pioneering work of Bourgain, Brezis, and Mironescu, there has been widespread interest in characterizing Sobolev and BV (bounded variation) functions by mean...