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Peripheral neuropathy risk and a transcobalamin polymorphism: connecting the dots between excessive folate intake and disease susceptibility
Peripheral neuropathy risk a transcobalamin polymorphism dot disease susceptibility
2018/12/19
Advances in the broad field of nutritional genomics continue to shed light on variable disease susceptibility to modifications in micronutrient intake within populations. This is certainly the case wi...
Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
folate folic acid peripheral neuropathy TCN2 776C>G polymorphism transcobalamin vitamin B-12
2018/12/19
Background: The 776C→G polymorphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is associated with a lower holotranscobalamin concentration in plasma. This ...
Folate intake of the Dutch population according to newly established liquid chromatography data for foods
Folate folate intake consumption survey
2016/6/13
Determining folate intake is difficult because
existing folate data in food-composition tables are scarce and
unreliable.
Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use
Homocysteine tHcy folate
2016/6/13
The serum total homocysteine concentration
(tHcy), an indicator of folate status and a possible risk factor for
vascular disease, is elevated with impaired renal function and
poor vitamin B-12 stat...
Validity of a self-administered food frequency questionnaire (FFQ) and its generalizability to the estimation of dietary folate intake in Japan
FFQ a self-administered food
2008/4/23
In an epidemiological study, it is essential to test the validity of the food frequency questionnaire (FFQ) for its ability to estimate dietary intake. The objectives of our study were to 1) validate ...
Folate catabolite excretion is responsive to changes in dietary folate intake in elderly women
Folate status folate catabolites folate depletion
2016/12/30
The major route of folate turnover is by catabolic cleavage of the C9-N10 bond producing p-aminobenzoylglutamate (pABG) and its primary excretory form, p-acetamidobenzoylglutamate (ApABG). We hypothes...
Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample
total homocysteine tHcy metabolism
2016/12/29
The objective of the study was to assess the effect of the polymorphism on the relations among folate intake, plasma folate concentration, and total plasma homocysteine (tHcy) concentration.
Dietary counseling to increase natural folate intake:a randomized,placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine
Folate folate intake homocysteine diet dietary counseling randomized trial community participants
2016/12/19
Background: The association between vascular disease and elevated plasma total homocysteine (tHcy) concentrations is caused, in part, by inadequate intakes of dietary folate. Increasing folate intake ...
Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women
Homocysteine women folate intake folic acid lifestyle vitamin supplements observational study
2016/6/8
Background: An elevated total homocysteine (tHcy) concentration
is considered to be an independent risk factor for cardiovascular
diseases and has also been associated with an increased
risk of neu...