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中国科学院动物研究所专利：MONOCLONAL ANTIBODY AGAINST HUMAN PRPC AND USE THEREOF
中国科学院动物研究所 专利 人PrPC蛋白 单克隆抗体
2024/5/31
一种抗人PrPC蛋白的单克隆抗体，能够以靶向方式降低转录因子Twist1的表达水平，并诱导巨噬细胞和NK细胞靶向直肠癌肿瘤细胞。 抗体与西妥昔单抗联合用药的抑瘤效果也优于单用抗体或西妥昔单抗。
A novel cancer therapeutic, combining antibody fragments with molecularly engineered nanoparticles, permanently eradicated gastric cancer in treated mice, a multi-institutional team of researchers fou...
A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Preventive medicine SARS-CoV-2 Viral infection
2020/6/11
An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally. Countermeasures are needed to treat and prevent ...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Rice University scientists have developed a method to efficiently modify natural antibodies that can deliver drugs to target cells. Adding a little extra metal is the key.Rice chemist Zachary Ball and...
Researchers uncover clues about how HIV virus mutates away from broadly neutralizing antibody
Researchers HIV virus mutates away broadly neutralizing antibody
2017/7/21
A new study published in Cell Host & Microbe led by researchers at Fred Hutchinson Cancer Research Center completely maps all mutations that help the HIV virus evolve away from a single broadly neutra...
Prenatal undernutrition, postnatal environments, and antibody response to vaccination in adolescence
infantile diarrhea vaccine nutrition adolescents
2016/6/14
Recently, researchers have considered the fetal
and infant origins of several adult cardiovascular and metabolic
diseases, but the implications of early events for immune function
and infectious di...
Antibody Evolution Constrains Conformational Heterogeneity by Tailoring Protein Dynamics
flexibility nonlinear spectroscopy fluorscein molecular recognition
2016/5/24
The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select ...
Development of a Novel, Anti-idiotypic Monoclonal Anti-prolactin Antibody That Mimics the Physiological Functions of Prolactin
Prolactin Anti-idotypic Antibody Signal Transduction
2016/5/20
In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was c...
Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor
Porcine Growth Hormone Porcine Growth Hormone Receptors Signalling Pathway Antagonist
2016/11/10
A series of antagonists specifically targeting growth hormone receptors (GHR) in different species, such as humans, rats, bovines, and mice, have been designed; however, there are currently no antagon...
Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome
Acute coronary syndrome Anticardiolipin antibodies
2015/7/22
Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was con...
TSRI and Biotech Partners Find New Antibody Weapons against Marburg Virus
TSRI Biotech Partners Weapons against Marburg Virus
2015/7/13
A new study led by scientists at The Scripps Research Institute (TSRI) identifies new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The research provides ingre...
PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
SIMPL Transcriptional Co-Activator NF-kB
2015/5/25
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal...
Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes
Monoclonal Anti-idiotypic Antibodies (Mab2s) Porcine Hepatocytes
2016/5/18
B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonis...
Asymmetries in Chickens from Lines Selected and Relaxed for High or Low Antibody Titers to Sheep Red Blood Cells
Chicken Asymmetry Selection Wattle Stress
2016/5/17
Wattle length, width, and area were measured to classify bilateral asymmetries in four lines of chickens. The lines were the S26 generation of White Leghorns selected for high (HAS) or low (LAS) respo...