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This article explores recent clinical developments of biological or targeted therapies in non-small cell lung cancer. Molecular research has given us a greater understanding of tumour biology and has ...
Elderly patients represent a significant and rising proportion of patients with Non-Small Cell Lung Cancer and historically they have been under-treated and under-represented in clinical trials. Incre...
Lung cancer is currently the leading cause of cancer-related death in both men and women in most Western countries. In Australia there is a falling incidence in males that is not matched in females, t...
In 1955, Bromley and Szur reported on 66 patients with a pathologic diagnosis of lung cancer who had been treated with high dose radiotherapy and who had then proceeded to surgery1. In 24 (46.7%) no t...
Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner (NSCLC) in progression after first-line chemotherapy. We evaluated...
Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis. We performed a retrospective stu...
Background and objective Approximately 30% of patients who are diagnosed with non-small cell lung cancer (NSCLC) are classified as N2 on the basis of metastasis to the mediastinal lymph nodes. The eff...
The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan, oxidized by CYP3A4 to produce inactive compounds, is u...
This study investigated quality of life (QOL) in patients with advanced non-small-cell lung cancer in an early phase of chemotherapy in a randomized phase III trial. QOL assessments for four domains (...
Cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). Many novel drugs have been used in combination with cisplatin in this setting. Of these drugs, g...

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