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Cyclophosphamide in the male rat：new pattern of anomalies in the third generation
Cyclophosphamide male rat anomalies third generation
2009/2/23
Several abnormalities, such as postnatal deaths and behavioral impairments, have been previously reported in the progeny of male rats exposed to the cytostatic drug cyclophosphamide 60 days prior to...
Effects of cyclophosphamide on selected cytosolic and mitochondrial enzymes in the epididymis of the rat
cyclophosphamide selected cytosolic mitochondrial enzymes epididymis rat
2009/2/23
The anticancer and immunosuppressive drug cyclophosphamide is extensively used in clinical practice and is known to alter fertility in man. We showed previously that treatment of male rats with lo...
Antimitotic drugs（cyclophosphamide and vinblastine）in the male rat. Deaths and behavioral abnormalities in the offspring
cyclophosphamide vinblastine male rat spermatogonia mutation offspring
2009/2/23
The spermatogenesis and the offspring of male rats treated either with cyclophosphamide alone, or with both cyclophosphamide and vinblastine were investigated. The offspring were evaluated for the...
Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia
Hormonal protection cyclophosphamide-induced inactivation rat stem spermatogonia
2009/2/13
Studies of protection of testicular function from cyclophosphamide with hormonal pretreatment have been limited by the lack of a convenient model for cyclophosphamide-induced inactivation of stem ...
Effects of the Chemotherapeutic Agents for Non-Hodgkin Lymphoma, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone（CHOP）, on the Male Rat Reproductive System and Progeny Outcome
Anticancer drugs spermatogenesis male germ cell apoptosis adverse effects developmental toxicity
2008/12/24
Chemotherapy of non-Hodgkin lymphoma (NHL) with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is associated with significant gonadal damage. Our goal was to determine the impact ...
Spermiogenic Germ Cell Phase–Specific DNA Damage Following Cyclophosphamide Exposure
Sperm comet assay chromatin remodeling susceptibility toxicology
2008/12/22
The production of genetically competent spermatozoa is essential for normal embryo development. The chemotherapeutic drug cyclophosphamide creates cross-links and DNA strand breaks in many cell type...