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p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
mast cells Pak1 allergic diseasis
2014/12/12
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
The p21activated kinase 1 (PAK1) belongs to PAKs family, a group of highly evolutionarily conserved protein family of serine/threonine kinases, which acts as a downstream effector of the small GTPase...