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The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells
allergic rhinitis carebastine CC chemokine histamine human nasal epithelial cells monocyte chemotactic protein-1 olopatadine RANTES
2010/11/18
The release of RANTES and MCP-1 was significantly upregulated by histamine compared with the control group. Both carebastine and olopatadine inhibited the release of CC chemokine production to the con...
Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Effects of orally administered olopatadine hydrochloride on the ocular allergic reaction in rats
conjunctivitis olopatadine rats
2010/11/24
The amount of dye leaking into the conjunctiva following passive anaphylaxis was significantly inhibited by oral administration of 0.01-1 mg/kg olopatadine and the ID50 value was 0.093 mg/kg. In the c...