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The Regulatory Role Of Matrix Metalloproteinases In T Cell Activation
T cell activation MMP9 Matrix Metalloproteinases
2015/5/25
Introduction: Matrix metalloproteinases (MMPs) are known for their role in extracellular matrix remodeling, but their role in regulating intracellular immune cell function is unknown. We reported that...
Dendritic Cells Bearing HLA-G Inhibit T-Cell Activation in Type 1 Diabetes
Dendritic cell HLA-G IFN-β (Interferon β)
2010/4/2
HLA-G is normally expressed on human trophoblast cells. It is a non-classical MHC molecule class I b. The role of HLA-G in diabetic type 1 is not known.We investigated the role of IFN-β in induction H...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...