搜索结果: 1-8 共查到“基础医学 G6PD”相关记录8条 . 查询时间(0.078 秒)
目的观察高糖环境下THP-1细胞葡萄糖-6-磷酸脱氢酶（G6PD）活性及呼吸爆发功能改变及其可能信号通路。方法利用蛋白激酶A（PKA）特异性抑制剂PKI和PKA激动剂Forskolin 预处理不同浓度葡萄糖培养的THP-1 细胞，检测不同处理组的G6PD活性、腺苷酸环化酶(cAMP)含量、ROS产量及磷酸化p47phox的表达变化。结果与正常对照组相比，高糖组及PKA激动组的G6PD活性、ROS产...
目的:观察去氢表雄酮（DHEA）及G6PD基因的全硫代修饰反义寡核苷酸对体外培养Raji细胞的抑制作用。 方法:分别用不同浓度DHEA及G6PD反义寡核苷酸作用于体外培养Raji细胞，观察细胞存活、生长情况，同时采用逆转录-聚合酶链反应检测Raji细胞G6PD基因mRNA表达水平，测定G6PD活性。 结果:DHEA及G6PD反义寡核苷酸不影响Raji细胞存活，50 μmol/L、500μmol/L...
应用变性高效液相色谱法检测G6PD基因G392T及C1024T
葡糖磷酸脱氢酶缺乏 突变 基因
2009/8/5
目的： 通过对葡萄糖-6-磷酸脱氢酶（G6PD）基因两种已知突变的检测，观察变性高效液相色谱法(denaturing high performance liquid chromatography, DHPLC)的实用价值。 方法: 应用DHPLC方法及脱氧核糖核酸序列测定对葡萄糖-6-磷酸脱氢酶缺乏症患者和正常对照者进行已知突变的检测。 结果: 正常对照者第5、9-10外显子为单峰；G6PDG39...
Glucose -6- Phosphate Dehydrogenase (G6PD) variants in East Sepik Province of Papua New Guinea: G6PD Jammu, G6PD Vanua Lava, and a novel variant (G6PD Dagua)
G6PD deficiency Papua New Guinea Dagua
2010/12/10
A community-based survey was conducted to assess the prevalence of G6PD deficiency and malaria in two villages (St. Martins, Dagua) of Wewak district, East Sepik Province, Papua New Guinea. A total of...
Glucose-6-phosphate dehydrogenase (G6PD) Deficiency
G6PD Oxidative damage Sex-linked inheritance Hemolytic anemia Mediterranean variant
2009/12/16
Glucose-6-phosphate dehydrogenase (G6PD) Deficiency is the most prevalent enzymopathy in mankind. It has sex-linked inheritance. This enzyme exists in all cells. G6PD deficiency increases the sen...
人类G6PD的分子生物学研究进展
G6PD 缺乏症 单体型 疟疾 DHPLC
2007/12/18
摘要 葡萄糖6磷酸脱氢酶（G6PD）缺乏症作为一种全球范围内最常见的酶缺乏症之一，受到研究者们的广泛关注。G6PD催化磷酸戊糖途径的第一步，由此酶催化生成的NADPH＋H＋对于对抗氧化性损伤是极其重要的。本文将从G6PD的结构与功能，SNP的研究与单体型的建立，抗疟选择优势与新的G6PD基因突变检测方法这几方面的研究进展综述如下。
A Patient with G6PD Deficiency and Falciparum Malaria
G6PD deficiency Falciparum Malaria Iran
2010/4/6
A 20 year old male patient from Afghanistan with a history of G6PD deficiency and clinical manifestations of malaria referred to Bou-Ali Hospital in Tehran, capital of Iran. Giemsa stained thick blood...
THE ASSOCIATION BETWEEN G6PD DEFICIENCY AND TOTAL SERUM BILIRUBIN LEVEL IN ICTERIC NEONATES
G6PDD Hyperbilirubinemia Favism Neonate
2010/4/19
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most important disease of the hexose monophosphate pathway. Deficiency of this enzym can lead to hemolysis of red blood cells. Our aim was to...