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Tyrosine requirement of healthy men receiving a fixed phenylalanine intake determined by using indicator amino acid oxidation
stable isotopes adult amino acid requirements Amino acid metabolism
2016/6/12
The currently accepted total aromatic amino acid
requirement for adults is based on nitrogen balance measurements
in individuals who received their intake of aromatic amino
acids solely as phenylal...
Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets
Phenylketonuria PKU tyrosine
2016/6/12
Treatment of phenylketonuria (PKU) consists
of restriction of natural protein and provision of a protein substitute
that lacks phenylalanine but is enriched in tyrosine. Large
and unexplained diffe...
Functional Insights Into Oncogenic Protein Tyrosine Phosphatases By Mass Spectrometry
Protein Tyrosine Phosphatases Mass Spectrometry
2015/5/25
Phosphatase of Regenerating Liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when overexpressed. To date, the molecular basis for PRL3 function remains an enigma, justif...
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
TrkB Alzheimer BACE1 SHC NFAT
2013/1/28
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has been reported that the...
Description of a Putative Oligosaccharyl:S-Layer Protein Transferase from the Tyrosine O-Glycosylation System of Paenibacillus alvei CCM 2051T
Bacterial Glycosylation S-Layer Oligosaccharyl Transferase
2013/1/29
Surface (S)-layer proteins are model systems for studying protein glycosylation in bacteria and simultaneously hold promises for the design of novel, glyco-functionalized modules for nanobiotechnology...
The Effects of Phenoxybenzamine on Tyrosine Hydroxylase (TH) and TH mRNA Level in Adrenal Medulla of Sprague Dawley Rats
Phenoxybenzamine tyrosine hydroxylase adrenal medulla TH mRNA
2009/7/6
The effects of anti-hipertensive phenoxybenzamine were in-vestigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were u...
Fms-like tyrosine kinase (Flt)-4 signaling participates in osteoclast differentiation in osteopetrotic (op/op) mice
Fms-like tyrosine kinase (Flt)-4 osteoclast differentiation osteopetrotic (op/op) mice
2009/5/8
Vascular endothelial growth factor (VEGF) induces osteoclast differentiation as well as neovascularization by binding to the fms-like tyrosine kinase (Flt)-1 and fetal liver kinase (Flk)-1 receptors...
目的：探讨血管生成素-1（Ang-1）对人脐静脉内皮细胞（HUVECs）内游离镁离子浓度（［Mg2+］i）的调节机制。方法:我们采用荧光指示剂mag-fura-2，运用PTi 阳离子测定系统动态测HUVECs的［Mg2+］i。结果:Ang-1诱导的［Mg2+］i增加与细胞外Mg2+浓度无关。Ang-1诱导的［Mg2+］i增加与细胞内Ca2+浓度无关。经酪氨酸激酶阻断剂(tyrphostin A23...
As a therapeutic target, protein tyrosine phosphatase 1B (PTP1B) has received considerable attention for the treatment of diabetes mellitus. A QSAR study using substituted monocyclic and polycyclic th...
Presence and tyrosine phosphorylation of c-met receptor in human sperm
tyrosine phosphorylation c-met receptor human sperm
2009/2/18
The c-met receptor is a p190MET tyrosine kinase proto-oncoprotein that through its binding to its ligand, designated hepatocyte growth factor (HGF), induces mitogenic, motogenic, and morphogenic act...
Regulation of sperm function by protein tyrosine phosphorylation in diverse wild felid species
Cat cAMP capacitation
2009/2/18
Protein tyrosine phosphorylation is associated with sperm capacitation and the acrosome reaction in several mammalian species. Changes in phosphorylation of a 95-kDa protein in human, mouse, and d...
Interaction between Ca2+, cyclic 3',5' adenosine monophosphate, the superoxide anion, and tyrosine phosphorylation pathways in the regulation of human sperm capacitation
Calmodulin phosphatase kinase
2009/2/17
In order to fertilize the egg, spermatozoa must go through the capacitation process where they experience Ca2+ uptake, increases in cyclic 3',5' adenosine monophosphate (cAMP) concentrations, supe...
Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor
GABAA receptor Cl- channel
2009/2/16
Previous studies showed that progesterone (P) can initiate the mammalian sperm acrosome reaction (AR) in vitro and that a sperm GABAA-like receptor/Cl- channel is involved in an essential Cl- effl...
Hexokinase present in human sperm is not tyrosine phosphorylated but its antibodies affect fertilizing capacity
Hexokinase human sperm fertilization infertility
2009/2/16
The present study was conducted to investigate the presence of hexokinase in human sperm cell, its subcellular localization, its modulation and role in capacitation/acrosome reaction, and tyrosine...
A redox-regulated tyrosine phosphorylation cascade in rat spermatozoa
Epididymal maturation cAMP-dependent phosphorylation
2008/12/29
Rat spermatozoa from both the caput and cauda epididymidis were shown to generate superoxide anion (O2-.) both spontaneously and following stimulation with NAD(P)H. Caput spermatozoa gave a signific...