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The role of SWI/SNF in regulating smooth muscle differentiation
Brm smooth muscle knockout
2015/5/22
There are many clinical diseases involving abnormal differentiation of smooth muscle, such as atherosclerosis, hypertension and asthma. In these diseases, one important pathological process is the dis...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma
Asthma Bronchoconstriction Fish Oil
2015/5/22
Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication o...
Differentiation and contractility of colon smooth muscle under normal and diabetic conditions
type 1 diabetes colon STZ
2015/5/22
Intestinal smooth muscle development involves complex transcriptional regulation leading to cell differentiation of the circular, longitudinal and muscularis mucosae layers. Differentiated intestinal ...
Serum response factor-dependent regulation of smooth muscle gene transcription
Smooth muscle cells Gene regulation MicroRNA Chromatin remodeling Serum Response Factor
2015/5/22
Several common diseases such as atherosclerosis, post-angioplasty restenosis, and graft vasculopathies, are associated with the changes in the structure and function of smooth muscle cells. During the...
Adrenergic and cholinergic responses of the tracheal smooth muscle is enhanced during estrus phase in rat
Acetylcholine estradiol estrous cycle isoproterenol tracheal smooth muscle
2010/10/14
The aim of this study was to evaluate influences of hormonal changes during rat estrous cycle on airway responsiveness to bronchoconstrictor and bronchodilator agents. Materials and methods: The study...
Involvement of Fibronectin and Matrix Metalloproteinases in Airway Smooth Muscle Cell Migration for the Process of Airway Remodeling
airway remodeling cell migration fibronectin matrix metalloproteinases smooth muscle cells
2010/11/12
The response of bSMC migration to bSMC-conditioned medium increased with time in culture, and fibronectin (FIB) was detected as a chemoattractant for bSMCs in bSMC-conditioned medium by western blot a...
A rheological constitutive equation for isotropic smooth muscle
A rheological constitutive equation isotropic smooth muscle
2010/1/7
A rheological constitutive equation for isotropic smooth muscle.
Synthesis and smooth muscle Calcium channel antagonist effect of Alkyl, Aminoalkyl 1,4-Dihydro-2,6-Dimethyl-4-Nitroimidazole-3,5 Pyridine Dicarboxylates
Ca+² channel antagonist DHP Arylpiperazine
2009/12/29
The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+² influx represented a major therapeutic advance in the treatment of cardiovascular diseases such ...
Synthesis and smooth muscle Calcium channel antagonist effects of new derivatives of 1,4-Dihydropyridine containing Nitroimidazol substituent
Dihydropyridine Calcium channels antagonist GPILSM
2009/12/29
A group of racemic 3-[(2-hydroxyethyl), (2-Methoxyethyl), (2-acetylethyl) or (2-cyanoethyl)], 5- methyl, ethyl or isopropyl-1, 4-dihydro-2, 6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3, 5-pyridinedi...
Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells
airway inflammation airway smooth muscle cells B7-H2 DNA synthesis inducible costimulator
2010/11/16
The data demonstrate that ASM cells express functionally active B7-H2, CD40 and OX40L and suggest that B7-H2-dependent signaling may play an active role in a proliferative response rather than in cyto...
Reduction of the incidence of decompression sickness in rats by smooth-muscle activating factor (SMAF)
decompression
2009/7/17
Normal rats were injected with a smooth-muscle activating factor (SMAF) to examine the dose-response relationshio of SMAF to the incidence of decompression sickness. After injections of saline or 1.0,...
Smooth Muscle Actin (SMA) Immunoreactivity in Primary Glomerulonephritis (GN)
Glomerulonephritis smooth muscle actin interstitium fibrosis
2009/6/29
The aims of this study were to determine the role of interstitial and glomerular myofibroblasts in the progression of various glomerulonephritis, and to assess the value of myofibroblasts in determini...
Effects of Cyclic Strain and Growth Factors on Vascular Smooth Muscle Cell Responses
Cyclic Strain Growth Factors Proliferation Gene Regulation Vascular Smooth Muscle Cells
2010/1/22
Under physiological and pathological conditions, vascular smooth muscle cells (SMC) are exposed to different biochemical factors and biomechanical forces. Previous studies pertaining to SMC responses ...
Characterization of prostaglandin E receptor subtypes involved in the relaxation of rabbit penile corpus cavernosum smooth muscle
prostaglandin E receptor subtypes rabbit penile corpus cavernosum smooth muscle
2009/3/3
Prostaglandin E (PGE) induces the penile erection in the mammalians. Receptors for PGE were characterized to 4 different subtypes (EP1—4). The effects of agonists for EP1—4 receptors were studied on...