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探讨前列腺特异性抗原（PSA）含量和前列腺癌（PCA）组织中Clusterin、Kindlin-2蛋白阳性表达的相关性，研究前列腺癌的治疗策略。方法：45例前列腺增生和55例前列腺癌组织应用免疫组织化学方法检测凋亡蛋白Kindlin-2、Clusterin的表达并检测对应病例的血浆PSA含量。
Clusterin在Anip973/CDDP细胞株中的表达及其意义
肺肿瘤 Clusterin p53基因 Bax肺肿瘤
2013/12/10
聚集素（Clusterin, CLU）在肿瘤发生发展过程中的作用及变化特点是国内外近年来关注的一个热点，但有关CLU在肺癌中表达变化与抗癌药物敏感性机制的研究目前仍无相关报道。本研究比较CLU在Anip973与Anip973/CDDP两种细胞系中的表达，探讨CLU与非小细胞肺癌耐药关系。方法 采用Western blot从蛋白水平比较CLU在Anip973和Anip973/CDDP中的差异表达，...
目的探讨肥大细胞、Clusterin/apoJ和转化生长因子-β（TGF-β）在不同时期血管瘤发生、发展过程中的表达及相关性。方法采用免疫组织化学方法检测不同时期血管瘤中Clusterin/apoJ、TGF-β的表达水平以及采用甲苯胺蓝染色法对各期肥大细胞进行染色。结果增生晚期肥大细胞计数明显多于增生早、中期（P<0.01），退化早期肥大细胞计数明显多于退化中、晚期（P<0.01）。Cluster...
Reproductive tract secretions and bull spermatozoa contain different clusterin isoforms that cluster cells and inhibit complement-induced cytolysis
Epididymal fluid rete testis fluid L-cells
2009/2/18
Clusterin from bull rete testis fluid (RTF), cauda epididymal fluid (CEF), and octyl-beta-D-glucopyranoside extract of cauda epididymal sperm (CES) was identified and characterized using monoclonal ...
Expression of clusterin/sulfated glycoprotein-2 under conditions of heat stress in rat Sertoli cells and a mouse Sertoli cell line
SGP-2 testis HSP7O
2009/2/17
Clusterin is the major protein produced by rat Sertoli cells and is deposited onto sperm membranes; however, its function is unknown. In order to gain insight into the regulation of clusterin in Serto...
Differential expression of clusterin in the testis and epididymis of postnatal and germ cell deficient mice
clusterin epididymis postnatal germ cell deficient mice
2009/2/16
Clusterin is found in a wide variety of tissues and is expressed in a number of physiological and pathological contexts. It is expressed constitutively in the adult male reproductive tract, specific...
Germ cell-conditioned medium contains multiple factors that modulate the secretion of testins, clusterin, and transferrin by Sertoli cells
Germ cell-conditioned medium testins clusterin Sertoli cells
2009/2/12
In view of the evidence showing that germ cells regulate Sertoli cell (SC) function, the aim of this study was to examine if germ cell (GC)-conditioned media contained multiple biological factors ...
Clusterin在大肠癌组织中的表达及其与临床病理特征的关系
Clusterin 大肠癌 凋亡
2014/4/10
观察凋亡抑制因子Clusterin在大肠癌组织中的表达及其与大肠癌发生、发展的关系。方法：收集广东医学院附属医院临床资料完整的大肠癌术后标本58例（其中直肠癌32例，结肠癌26例），采用免疫组织化学SP法检测大肠癌组织、癌旁组织和正常大肠组织中Clusterin的表达情况,流式细胞术检测大肠癌组织中肿瘤细胞凋亡的情况。结果： Clusterin在大肠癌组织中的阳性表达率明显高于大肠癌癌旁组织和大肠...
Endocytosis of androgen-binding protein, clusterin, and transferrin in the efferent ducts and epididymis of the ram
Testicular proteins uptake excurrent ducts
2009/2/7
The amount of androgen-binding protein (ABP) in luminal fluid from the central caput epididymidis of the ram, on a per sperm basis, remains the same as that in rete testis fluid (RTF) entering the...
Localization of clusterin on freeze-preserved bull spermatozoa before and after glass wool-sephadex filtration
Immunofluorescence abnormal spermatozoa semen
2008/12/29
Clusterin is a major protein in bull reproductive tract secretions and sperm membrane extract. A polyclonal antibody was produced against clusterin from bull cauda epididymal fluid (CEF) and used fo...
Effect of scrotal insulation on clusterin-positive cells in ram semen and their relationship to semen quality
Clusterin abnormal spermatozoa semen analysis
2008/12/29
Scrotal contents of 2 rams were insulated for 96 hours and the fraction (as a percentage) of clusterin-positive cells (CPCs) and its relationship to semen quality was investigated. Semen collection ...
Correlation between clusterin-positive spermatozoa determined by flow cytometry in bull semen and fertility
Correlation clusterin-positive spermatozoa cytometry bull semen fertility
2008/12/25
The objectives were to 1) develop a rapid and accurate method for detection of clusterin-positive spermatozoa (CPS) in bull semen and 2) determine the utility of incidence of CPS for prediction of f...