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Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
Brown Norway rat accelerated germ cell apoptosis luteinizing hormone replacement
2009/2/18
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination ...
The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat
seminiferous epithelium blood-testis barrier Brown Norway rat
2009/2/18
Steroidogenesis and spermatogenesis decrease in aging Brown Norway rats. We therefore hypothesized that there must be accompanying morphological changes taking place in the seminiferous tubules of...
Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?
Aging testis steroids rat
2009/2/18
Previous studies have shown that reductions in Leydig cell testosterone production occur with aging in the Brown Norway rat. The recent observation that changes in luteinizing hormone (LH) pulse i...
The effects of aging on the expression of glutathione S-transferases in the testis and epididymis of the Brown Norway rat
glutathione S-transferases epididymis Brown Norway rat
2009/2/17
Glutathione S-transferases (GSTs), a family of isoenzymes, catalyze the conjugation of glutathione to a variety of electrophiles, and protect cellular constituents from electrophilic and oxidative...
In the male brown-Norway (BN) male rat, reproductive aging is associated with decreased LH-pulse amplitude and area
FSH testosterone pulsatile secretion
2009/2/17
The Brown-Norway (BN) rat has been proposed as a rodent model for the study of human male reproductive aging. As in man, reduction in serum or plasma testosterone (T) and both testicular (primary)...
Gene expression in the aging brown Norway rat epididymis
Gene expression aging brown Norway rat epididymis
2009/2/13
The mammalian epididymis is the site where spermatozoa are matured and then stored. Though many studies have described epididymal functions and their regulation, little is known about how aging af...
Age-related decreased Leydig cell testosterone production in the brown Norway rat
Aging Leydig cell testosterone LII Brown Norway
2009/2/13
Previous studies have demonstrated that Leydig cell testosterone production diminishes with age in Brown Norway rats. The objective of the studies presented herein was to test the following possible...
Testicular steroidogenesis in the aging brown Norway rat
Aging testis steroidogenesis Leydig cell rat
2009/2/12
In seeking an animal model of age-associated changes in the male reproductive tract, we examined the effects of age on the health and testicular steroidogenic activity of the Brown Norway rat, with ...
The effect of aging on the seminiferous epithelium of the brown Norway rat
seminiferous epithelium brown Norway rat
2009/2/12
Aging of the mammalian testis is often accompanied by loss of germ cells and, as a result, decreased daily sperm production. It is currently unknown whether cell loss is the result of aging-related ch...
Sperm structural and motility changes during aging in the Brown Norway rat
Sperm structural motility changes Brown Norway rat
2008/12/26
The Brown Norway rat provides a useful model to study aging of the male reproductive tract because of the selective age-dependent pathological changes that are found in the testis, epididymis, and pro...
Age-related decrease in hypothalamic gonadotropin-releasing hormone（GnRH）gene expression, but not pituitary responsiveness to GnRH, in the male Brown Norway rat
Age-related decrease hypothalamic gonadotropin-releasing hormone（GnRH）gene expression pituitary responsiveness GnRH male
2008/12/25
As is the case in humans, aging male Brown Norway (BN) rats exhibit both primary and secondary (hypothalamic/pituitary) testicular failure. We hypothesized that secondary testicular failure in aging...
Spermatozoa Have Decreased Antioxidant Enzymatic Capacity and Increased Reactive Oxygen Species Production During Aging in the Brown Norway Rat
Oxidative stress epididymis glutathione peroxidase superoxide dismutase reproduction sperm
2008/12/24
As the proportion of aged males attempting to reproduce continues to rise, so does the concern regarding the quality of spermatozoa from aged men. An imbalance between the generation of reacti...
Rho-kinase Inhibition Improves Erectile Function in Aging Male Brown-Norway Rats
Muscle smooth drug effects penis physiology biological aging penile erection
2008/12/23
Physiological aging is a significant risk factor in the on-set of male erectile dysfunction (ED) and an imbalance in factors that modulate cavernosal smooth-muscle tone may play a role in these altere...
Alteration of endogenous corticosteroids and catecholamines in allergen-induced eosinophilic inflammation in Brown Norway rats
airway inflammation asthma Brown Norway rat endogenous corticosteroid metabolic cage urinary catecholamine excretion urinary 11-hydroxycorticosteroid excretion
2010/11/29
Although various types of stress activate a pituitary adrenal response, the alteration of endogenous corticosteroids and catecholamines during asthma remains unclear. The aim of this study was to asse...
The Phosphodiesterase 4 Inhibitor Prevents Antigen-induced Biphasic Nasal Obstruction in Brown Norway Rats
acoustic rhinometry allergic rhinitis BN rat nasal obstruction PDE inhibitor
2010/11/22
Background: Nasal obstruction is considered the most serious problem for patients with allergic rhinitis. We have previously established a model of nasal obstruction in guinea pigs. In the present stu...