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An enzyme can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study. The findings are published in the journal Nature.By restricting the dietary ami...
The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A ...
Breast cancer is the most frequent tumor type among women. Heightened susceptibility of the breast to tumor development has been associated with early menarche, nulliparity, exposures to ionizing radi...
Despite current advances in understanding breast cancer, in 2007 an estimated 178,480 new cases were diagnosed in female patients in the United States, and an estimated 40,640 deaths will occur due to...
PATHWAYS CONTRIBUTING TO DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS IN BALB/c-Trp53+/- MICE Mutation and loss of p53 function are common features among human breast cancers. We use BALB/c-Trp53+/- mice...
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
In a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation...
Tolerance mechanisms, which collectively work to prevent autoimmunity, play a key role in suppressing the adaptive immune response to tumor antigens. This phenomenon is attributed to the extensive ove...
The combination of cytotoxic therapies and anti-angiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments ...
The speed and the versatility of today's computers open up new opportunities to simulate complex biological systems. Here we review a computational approach recently proposed by us to model large tumo...
In the present paper we study a lattice tumor-growth model. Monte Carlo simulations for $d=$1, 2, and 3 show that when nutrients are easily available, normal and tumor cells coexist. However, when the...
Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has...
We performed a genome-wide linkage and quantitative trait locus (QTL) analysis to confirm the existence of QTL affecting Rous Sarcoma Virus (RSV) induced tumor regression, and to estimate their effect...
为了探讨不同肿瘤组织中线粒体基因体细胞性突变的胞质异质性和同质性状态,利用32对重叠引物对149例肿瘤组织和匹配的正常组织的全线粒体基因进行PCR扩增,并同时进行时相温度梯度凝胶电泳扫描突变筛选,基因测序确定突变类型与异质状况。结果表明,不同肿瘤组织中线粒体基因体细胞性突变的异质率不同,口腔癌(65%)和食道癌(64%)具有较高的异质率,其次为乳腺癌(45.9%)。4种转换形式的发生频率Hm→Hm...

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