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One of the most important classes of human enzymes are protein kinases — signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism. Dysfunction ...
Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of...
Enzyme treatment of skin samples improves microbiome analysis
bacterial skin microorganism skin disease
2021/8/11
Healthy skin has a bacterial shield to protect against germs: the microbiome. This complex assembly of microorganisms was previously believed to be difficult to decipher. A team of researchers has now...
Scientists ID enzyme for making key industrial chemical in plants
p-hydroxybenzoic acid CRISPR/Cas9 gene
2021/8/6
Scientists studying the biochemistry of plant cell walls have identified an enzyme that could turn woody poplar trees into a source for producing a major industrial chemical. The research could lead t...
华南理工大学酶工程课件 Enzyme enignnering。
Oxidative Stress and Antioxidant Enzyme Defence System in Seminal Plasma of Common Carp (Cyprinus carpio) and Rainbow Trout (Oncorhynchus mykiss) during Spawning Season
reproductive season lipid peroxidation products fish sperm superoxide dismutase glutathione reductase glutathione peroxidase
2018/3/5
Assessment of seminal oxidative stress indicators is emerging as a valuable prognostic tool in assisted reproductive
technology. We investigated levels of oxidative stress caused by reactive oxygen s...
Artificial Enzyme:Protein Designed Entirely From Scratch Functions In Cells As A Life-Sustaining Catalyst（图）
Artificial Enzyme Protein Designed Entirely Scratch Functions In Cells Life-Sustaining Catalyst
2018/2/1
A dawning field of research, artificial biology, is working toward creating a genuinely new organism. At Princeton, chemistryprofessor Michael Hecht and the researchers in his lab are d...
Enzyme Shown To Regulate Inflammation And Metabolism In Fat Tissue（图）
Enzyme Regulate Inflammation Metabolism Fat Tissue
2018/1/31
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered intere...
Old enzyme,new role
Old enzyme new role
2017/2/16
A team of researchers at the University of Delaware has discovered a new function for an enzyme that has long been known to have a central role in bacterial metabolism.Maciek Antoniewicz, Centennial J...
Researchers Tweak Enzyme ‘Assembly Line’ to Improve Antibiotics
Researchers Enzyme Assembly Line Improve Antibiotics
2016/12/13
Acyltransferase (AT) domains of polyketide synthases (PKSs) select extender units for incorporation into polyketides and dictate large portions of the structures of clinically relevant natural product...
UChicago scientists identify enzyme that removes molecular modifications from transfer RNA
UChicago scientists enzyme molecular modifications transfer RNA
2016/11/4
New research by scientists from the University of Chicago demonstrates that the mammalian enzyme ALKBH1 can remove molecular modifications from transfer RNA, causing a measurable effect on protein tra...
Dissecting Proton Delocalization in an Enzyme’s Hydrogen Bond Network with Unnatural Amino Acids
Dissecting Proton Delocalization Enzyme’s Hydrogen Bond Network Unnatural Amino Acids
2016/5/25
Extended hydrogen bond networks are a common structural motif of enzymes. A recent analysis proposed quantum delocalization of protons as a feature present in the hydrogen bond network spanning a tria...
Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site
ab initio path integral molecular dynamics enzyme hydrogen bonding nuclear quantum effects proton delocalization
2016/5/25
Enzymes use protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here, we use experiments, combined with ab init...
A Thermodynamic Framework For Identifying Free Energy Inventories of Enzyme Catalytic Cycles
Steroid Isomerases Catalysis Hydrogen-Ion Concentration Thermodynamics Models, Chemical
2016/5/25
Pauling's suggestion that enzymes are complementary in structure to the activated complexes of the reactions they catalyze has provided the conceptual basis to explain how enzymes obtain their fantast...
Quantitative,Directional Measurement of Electric Field Heterogeneity Within an Enzyme Active Site
Quantitative Directional Measurement Electric Field Heterogeneity Enzyme Active Site
2016/5/25
Extensive structural studies of enzymes have revealed that biological catalysis occurs within sequestered active site crevices, where reacting substrates are surrounded by an anisotropic and chemicall...