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the KATP channels are inhibited by direct ATP binding to the Kir pore-forming subunit, preventing K+ flux across the membrane ,sarcolemma (sarcKATP) membrane the inner membrane of the mitochondria.
Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress
Mitochondrial ATP-Sensitive Oxidative Stress
2014/3/31
ptosis contributes to ischemic injury in the brain,
4
and
brain mitochondria contain 7 times more mitoK
ATP
channels
than heart mitochondria.
5
Several reports have shown that
mitoKATP
chann...