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Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial
DNA methylation epigenetics EWAS Illumina 450k methylation array LIPOGAIN cohort obesity overfeeding polyunsaturated fat prediction saturated fat
2018/11/13
Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) h...
Repeats as global DNA methylation marker in bovine preimplantation embryos
epigenetics retrotransposon bisulfite sequencing
2017/2/21
DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a...
Characterization of the Methylation Status of Pax7 and Myogenic Regulator Factors in Cell Myogenic Differentiation
Pax7 Myogenic Regulatory Factors C2C12 DNA Methylation CpG Islands
2016/7/27
Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade. DNA methylation is a major epigenetic modification important for regulating gene expression and supp...
Analysis of Histone Lysine Methylation Using Mass Spectrometry
MudPIT histones transcription
2015/5/25
Histones are highly basic proteins which when digested by trypsin are hard to analyze using mass spectrometry. Because histones are basic nuclear proteins, a nuclei prep followed by acid extraction is...
LIM homeodomain 3 (LHX3) is an important regulator of pituitary and nervous system development. To date, twelve LHX3 gene mutations have been identified in patients with combined pituitary hormone def...
A new strategy for RNA structure probing in vivo: Targeting methylation small nucleolar RNPs to new sites in ribosomal RNA
Eukaryotic ribosomal RNA nucleotide RNA proteins DNA methylation
2014/12/11
Eukaryotic ribosomal RNAs (rRNAs) contain scores of 2′-O-methylated nucleotides that are formed by a large family of small RNA:protein machines called snoRNPs. The snoRNPs contain a small nucleolar RN...
Association of DNA Methylation Levels with Tissue-specific Expression of Adipogenic and Lipogenic Genes in Longissimus dorsi Muscle of Korean Cattle
Adipogenesis DNA Methylation Intramuscular Fat Korean Cattle
2016/5/17
Epigenetic factors, such as DNA methylation status, may regulate adipogenesis and lipogenesis, thus affecting intramuscular fat (IMF) deposition in longissimus dorsi muscle (LM) of beef cattle. In Kor...
Investigation of Deletion Variation and Methylation Patterns in the 5' LTR of Porcine Endogenous Retroviruses
Pigs Long Terminal Repeat (LTR) Porcine Endogenous Retroviruses (PERVs) Xenotransplantation
2016/4/28
The xenotransplantation of pig organs and cells can be related with a risk of transmission of infectious diseases to human. Previous findings indicate that the regulatory region of PERV for retroviral...
DNA甲基化与组蛋白甲基化的关系The Relationship of DNA Methylation and Histone Methylation
DNA 组蛋白 甲基化 甲基转移酶
2008/1/10
摘要在真核生物基因组及基因组以外，存在着多种共价修饰，其中，DNA和组蛋白的甲基化都与基因的沉默存在着联系，DNA和H3K9的甲基化在调节基因过程中具有协同作用，并拮抗H3K4的甲基化。近来的研究显示，两种甲基化机制之间似乎还存在着联系，即DNA的甲基化可能依赖于H3K9的甲基化，但在哺乳动物中，两种甲基化的关系可能更复杂。 Abstract: In and out of the eukaryot...
摘要
主要阐述了组蛋白甲基转移酶的类型，组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控，以及与DNA甲基化之间的关系，说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系, 指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。
Abstract： The types of histone methyltransferases, the relationship...
宫颈癌p16基因甲基化及表达的研究 Methylation and Aberrant Expression of the p16 Gene in Cervical Carcinoma
宫颈癌 p16基因表达 甲基化
2008/1/6
摘要
为了探讨p16基因甲基化及异常表达在宫颈癌中的意义，分别采用甲基化特异性PCR（MSP）方法检测不同病理类型和临床分期的60例宫颈癌组织中p16基因启动子区域5´CpG岛甲基化状态；采用PCR方法检测p16基因外显子1（E1)和外显子2(E2)纯合缺失情况;采用免疫组化的方法分析p16蛋白的表达缺失和减弱情况。结果显示正常对照组织及癌旁p16基因无甲基化，且无E1和E2缺失和p...
Genome-wide DNA Methylation Profiles of Small Intestine and Liver in Fast-growing and Slow-growing Weaning Piglets
DNA Methylation MBD-seq Epigenetic Profile Weaning Piglet Genome-wide Methylation Profile
2016/5/17
Although growth rate is one of the main economic traits of concern in pig production, there is limited knowledge on its epigenetic regulation, such as DNA methylation. In this study, we conducted meth...